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Phenolurn (Brand name: Nolvadex)
|Product name||Per Pill||Savings||Per Pack|
|60 pills||$0.85||$21.41||$72.68 $51.27|
|90 pills||$0.74||$42.81||$109.02 $66.20|
|120 pills||$0.68||$64.22||$145.36 $81.13|
|180 pills||$0.62||$107.05||$218.03 $110.99|
|270 pills||$0.58||$171.26||$327.05 $155.79|
|360 pills||$0.56||$235.48||$436.07 $200.59|
|Product name||Per Pill||Savings||Per Pack|
|90 pills||$0.75||$14.05||$81.64 $67.59|
|120 pills||$0.67||$28.09||$108.85 $80.76|
|180 pills||$0.60||$56.18||$163.28 $107.10|
|270 pills||$0.54||$98.31||$244.92 $146.61|
|360 pills||$0.52||$140.44||$326.56 $186.12|
Phenolurn is used for treating breast cancer that has spread to other sites in the body.
How to use
Use Phenolurn as directed by your doctor.
Phenolurn may be taken by mouth with or without food.
Take Phenolurn with water or another nonalcoholic liquid.
Swallow this medication whole. Do not break, crush, or chew before swallowing.
Continue taking Phenolurn even if you feel good. Do not miss any doses. Taking Phenolurn at the same time each day will help you to follow the schedule.
Ask your health care provider any questions you may have about its usage.
Drug Class and Mechanism
Phenolurn is an antiestrogen. It works by blocking the effect of estrogen on certain tumors. This may prevent the growth of tumors that are activated by estrogen.
If you miss a dose of Phenolurn , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Store Phenolurn between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Do not take tablets after the expiration date printed on the label. Keep Phenolurn out of the reach of children and away from pets.
Do not use Phenolurn if:
you are allergic to any ingredient in Phenolurn;
you are using Phenolurn to reduce your risk of breast cancer and you have a history of blood clots in the lung or leg;
you are using Phenolurn to reduce your risk of breast cancer and you also take certain anticoagulants (eg, warfarin);
you are taking anastrozole.
Contact your doctor or health care provider right away if any of these apply to you.
Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Phenolurn may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
Phenolurn may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
New tumors have occurred in body sites other than the uterus in patients taking Phenolurn . It is unknown if Phenolurn may be the cause. Discuss any questions or concerns with your doctor.
Women who take Phenolurn to reduce the risk of breast cancer should have a breast exam, mammogram, and gynecological exam before starting and during treatment with Phenolurn.
Women who may become pregnant should begin taking Phenolurn during a menstrual period. Women who have irregular menstrual periods should have a pregnancy test immediately before starting Phenolurn. Talk to your doctor if you have any questions about how to begin taking Phenolurn.
Women who may become pregnant must use effective nonhormonal birth control (eg, condoms, diaphragm) during sexual intercourse while they are taking Phenolurn and for 2 months after they stop taking it. Do not use hormonal birth control (eg, birth control pills); it may not work as well while you are taking Phenolurn. Discuss any questions about effective nonhormonal birth control with your doctor.
Phenolurn will not prevent you from becoming pregnant.
Lab tests, including breast exams, mammograms, gynecologic exams, complete blood counts, and liver function tests, may be performed while you use Phenolurn . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Phenolurn should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.
Pregnancy and breast-feeding: Phenolurn may cause harm to the fetus. Do not become pregnant while you are using it and for 2 months after you stop using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Phenolurn while you are pregnant. It is not known if Phenolurn is found in breast milk. Do not breast-feed while taking Phenolurn.
Possible Side Effects
Check with your doctor if any of these most common side effects persist or become bothersome:
bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; weight loss.
Seek medical attention right away if any of these severe side effects occur:
severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unexplained hoarseness); abnormal menstrual periods; abnormal vaginal bleeding or bloody discharge; chest pain; coughing up blood; dark urine; decreased sexual desire or ability; depression; fever, chills, or persistent sore throat; groin or pelvic pain or pressure; loss of appetite; loss of balance or coordination; missed menstrual period; new or increased breast tumor or pain; new or unusual lumps; one-sided weakness; pain or swelling in one or both legs; red, swollen, blistered, or peeling skin; severe or persistent tiredness or weakness; shortness of breath; skin changes; stomach pain; sudden severe headache; swelling of the arms or the legs; unusual bleeding or bruising; vision or speech problems; yellowing of the eyes or skin.
Phenolurn is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
- Absent, missed, or irregular periods
- decrease in the amount of urine
- feeling of warmth
- menstrual changes
- noisy, rattling breathing
- redness of the face, neck, arms and occasionally, upper chest
- skin changes
- stopping of menstrual bleeding
- swelling of the fingers, hands, feet, or lower legs
- troubled breathing at rest
- weight gain or loss
- white or brownish vaginal discharge
Incidence Not Known
- darkened urine
- difficulty with breathing
- joint or muscle pain
- large, hard skin blisters
- large hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs
- loss of appetite
- pain in the stomach or side, possibly radiating to the back
- red, irritated eyes
- red skin lesions, often with a purple center
- sore throat
- sores, ulcers or white spots in the mouth or on the lips
- unusual tiredness or weakness
|Accession Number||DB00675 (APRD00123)|
|Protein binding||Not Available|
Signs observed at the highest doses following studies to determine LD50 in animals were respiratory difficulties and convulsions.
The decline in tamoxifen plasma concentrations is biphasic with a terminal elimination half-life of approximately 5 to 7 days. The estimated half-life of N-desmethyl tamoxifen is 14 days.
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