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Phergan (Brand name: Phenergan)

  • $0.38
  • Brand name: Phenergan
  • Availability: In Stock
  • Active Ingredient Promethazine
Phergan is treating different types of allergy symptoms, including itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.
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25 mg
Product name Per Pill Per Pack  
60 pills $0.53 $31.63
90 pills $0.47 $47.44 $42.12
120 pills $0.44 $63.25 $52.62
180 pills $0.41 $94.88 $73.62
270 pills $0.39 $142.32 $105.11
360 pills $0.38 $189.76 $136.62

Product Description

Common use

Phergan is an antihistamine  used to treat different types of allergy symptoms, including itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. It works by decreasing the effects of histamine, a chemical the body releases in response to certain irritants. Also Phenegran is used as a sedative and sleep aid for all types of patients and prevent or control nausea and vomiting, treat motion sickness. You can use it with other medications, for pain after surgery also.

Dosage and direction

Take it orally with or without food/milk. It is better take this medication with food if you want to avoid stomach upset. For treating allergy the recommended dose is 25 mg before sleeping. You can repeat the dose within two hours if necessary. For treating motion sickness the recommended dose is 25 mg twice daily.
Note: this instruction presented here just for review. It's very necessary to consult  your doctor before using. It will help you to get better results.

Precautions

Do not give this drug to patients in coma. Do not use alcohol while taking Phergan because it can extreme drowsiness. Avoid alcohol use. Phergan may increase sensitivity to sunlight. Wear a sunscreen and protective clothing when you are exposed to the sun, it'll help you to avoid a heat stroke. Phergan should not be used during pregnancy, becoming pregnancy or lactating without telling your doctor. Do not use before breast-feeding without doctor's advice.

Contraindications

Phergan is not allowed to children under 2 years of age. Phergan is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. Also this drug is contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.

Possible side effect

They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include:
twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
feeling restless, jittery, or agitated;
high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;
feeling like you might pass out;
seizure (convulsions);
pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;
decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;
hallucinations, agitation;
nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);
urinating less than usual or not at all;
joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or
slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious include:
dizziness, drowsiness, anxiety;
blurred vision, dry mouth, stuffy nose;
ringing in your ears;
weight gain, swelling in your hands or feet;
impotence, trouble having an orgasm; or
constipation.
If you experience one of them stop using Phenegran and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction

Phergan interact with such drugs as:
lithium (Eskalith, Lithobid);
atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop); blood pressure medication such as guanadrel (Hylorel), guanethidine (Ismelin), propranolol (Inderal), and others; a blood thinner such as warfarin (Coumadin); bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva); bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), and others; an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), selegiline (Eldepryl, Emsam); medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma); medicine to treat stomach ulcer or irritable bowel syndrome, such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), mepenzolate (Cantil), or propantheline (Pro-Banthine). Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Overdose

Symptoms of Phergan overdose may include: severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting. If you experience one of them call your doctor immediately.

Storage

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Incidence Not Known

  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • blood in urine or stools
  • bloody nose
  • blurred vision
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • confusion as to time, place, or person
  • cough or hoarseness
  • dark urine
  • decreased awareness or responsiveness
  • difficulty or troubled breathing
  • double vision
  • fast, pounding, or irregular heartbeat or pulse
  • fever with or without chills
  • fixed position of eye
  • headache
  • heavier menstrual periods
  • high fever
  • holding false beliefs that cannot be changed by fact
  • hyperexcitability
  • increased or decreased blood pressure
  • increased sweating
  • irregular, fast or slow, or shallow breathing
  • itching
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • loss of appetite
  • loss of bladder control
  • lower back or side pain
  • mimicry of speech or movements
  • mutism
  • nasal stuffiness
  • nausea
  • negativism
  • nightmares
  • noisy breathing
  • not breathing
  • painful or difficult urination
  • pale or blue lips, fingernails, or skin
  • peculiar postures or movements, mannerisms or grimacing
  • pinpoint red spots on skin
  • seeing double
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe muscle stiffness
  • severe sleepiness
  • shortness of breath
  • skin rash
  • slow or irregular heartbeat
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • sticking out of tongue
  • swollen glands
  • tightness in chest
  • tremors
  • uncontrolled twisting movements of neck
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • vomiting of blood
  • wheezing
  • yellow eyes or skin
  • blistering, crusting, irritation, itching, or reddening of skin
  • continuing ringing or buzzing or other unexplained noise in ears
  • cracked, dry, scaly skin
  • dizziness
  • drowsiness
  • excitation
  • false or unusual sense of well-being
  • hearing loss
  • hives or welts
  • increased sensitivity of skin to sunlight
  • lack of coordination
  • loss of strength or energy
  • muscle pain or weakness
  • redness or other discoloration of skin
  • relaxed and calm
  • sunburn
  • swelling
  • unable to sleep
  • vomiting
Type Small Molecule
Accession Number DB01069  (APRD00601)
Groups Approved, Investigational
Synonyms
  • (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
  • 10-(2-Dimethylaminopropyl)phenothiazine
  • 10-[2-(dimethylamino)Propyl]phenothiazine
  • N-(2'-dimethylamino-2'-Methyl)ethylphenothiazine
  • N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine
  • N,N,α-trimethyl-10H-phenothiazine-10-ethanamine
  • Proazamine
  • Prometazina
  • Promethazine
  • Promethazinum
UNII FF28EJQ494
CAS number 60-87-7
Weight Average: 284.419
Monoisotopic: 284.13471934
Chemical Formula C17H20N2S
InChI
InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
IUPAC Name
dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine
Protein binding

93%

Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Half life

16-19 hours

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  • Algiers
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  • Tizi Ouzou