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PMS-Isoniazid (Brand name: Isoniazid)

  • $0.38
  • Brand name: Isoniazid
  • Availability: In Stock
  • Active Ingredient
PMS-Isoniazid is used for treating or preventing tuberculosis.
Other names of PMS-Isoniazid (Brand name: Isoniazid): a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
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300 mg
Product name Per Pill Per Pack  
60 pills $0.58 $34.66
90 pills $0.50 $51.98 $44.91
120 pills $0.46 $69.31 $55.18
180 pills $0.42 $103.97 $75.69
270 pills $0.39 $155.95 $106.46
360 pills $0.38 $207.94 $137.23

INDICATIONS

PMS-Isoniazid is used for treating or preventing tuberculosis (TB). If you are using PMS-Isoniazid to treat TB, it should always be used along with another medicine. PMS-Isoniazid is an antibacterial. It works by killing TB organisms.soniazid also has an antidepressant effect, and it was one of the first antidepressants discovered. PMS-Isoniazid can also be used in the treatment of a BCG-oma.

INSTRUCTIONS 

Use PMS-Isoniazid as directed by your doctor.

  • Take each dose with a full glass (8 ounces) of water.
  • Take PMS-Isoniazid on an empty stomach 1 hour before or 2 hours after meals. If nausea occurs, ask your doctor if you can take PMS-Isoniazid with food.
  • Take all of the PMS-Isoniazid that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.
  • It is important to take PMS-Isoniazid regularly to get the most benefit.
  • Your doctor may also want you to take a supplemental vitamin B6 (pyridoxine) tablet daily during treatment to prevent numbness and tingling caused by low levels of this vitamin.
  • Your doctor may want you to have blood tests or other medical evaluations during treatment with isoniazid to monitor progress and side effects.
  • Continue to use PMS-Isoniazid even if you feel well. Do not miss any dose.
  • If you miss a dose of PMS-Isoniazid, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use PMS-Isoniazid.

STORAGE

 Store PMS-Isoniazid between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep PMS-Isoniazid out of the reach of children and away from pets.


SAFETY INFORMATION

Do NOT use PMS-Isoniazid if:

  • you are allergic to any ingredient in PMS-Isoniazid or have had severe side effects from isoniazid, such as drug fever, chills, or arthritis
  • you have severe liver damage, active liver disease, or liver damage from previous use of PMS-Isoniazid
  • you have a history of hepatitis caused by any medicine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with PMS-Isoniazid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have diabetes, kidney problems, nerve problems (eg, neuropathy) or risk of nerve problems, HIV, or a history of liver problems
  • if you have a history of alcohol or other substance abuse, have unsanitary injectable drug habits, or drink alcohol daily
  • if you are older than 35 years old, you have recently given birth, or you have previously taken PMS-Isoniazid.

Some medicines may interact with PMS-Isoniazid. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Acetaminophen, anticoagulants (eg, warfarin), carbamazepine, hydantoins (eg, phenytoin), rifampin, theophylline, or valproic acid because the risk of their side effects may be increased by PMS-Isoniazid
  • Ketoconazole because its effectiveness may be decreased by PMS-Isoniazid.

This may not be a complete list of all interactions that may occur. Ask your health care provider if PMS-Isoniazid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Check with your doctor before drinking alcohol while using PMS-Isoniazid. Alcohol may increase the risk of liver problems. If you have a history of alcohol abuse, you may also be at increased risk of developing nerve problems from PMS-Isoniazid. Notify your doctor if you notice any unusual tingling or numbness in your hands or feet.
  • If you have a history of diabetes, alcohol abuse, or poor nutrition, your doctor may recommend that you also take vitamin B6 while you are taking PMS-Isoniazid. This may help to decrease your risk of nerve problems. Discuss any questions with your doctor.
  • Do not eat foods high in tyramine while you use PMS-Isoniazid. Eating foods high in tyramine (eg, aged cheeses, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) while you use PMS-Isoniazid may cause severe high blood pressure. Seek medical attention at once if symptoms of severe high blood pressure occur. These may include severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light.
  • Do not eat foods high in histamine while you use PMS-Isoniazid. Eating foods high in histamine (eg, skipjack, tuna, tropical fish) while you use PMS-Isoniazid may cause low blood pressure, irregular heartbeat, headache, sweating, or flushing. Contact your doctor at once if any of these symptoms occur.
  • Ask your health care provider for a complete list of all foods you should avoid while you are using PMS-Isoniazid.
  • PMS-Isoniazid only works against TB bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use PMS-Isoniazid for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Diabetes patients - PMS-Isoniazid may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. You may also be at increased risk of developing nerve problems from PMS-Isoniazid. Contact your doctor if you notice any unusual tingling in your hands or feet.
  • Lab tests, including liver function and eye exams, may be performed while you use PMS-Isoniazid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use PMS-Isoniazid with caution in black and Hispanic women; they may have a greater risk of severe liver problems from PMS-Isoniazid.
  • Use PMS-Isoniazid with caution in patients older 35 years; they may have a greater risk of severe liver problems from PMS-Isoniazid.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using PMS-Isoniazid while you are pregnant. PMS-Isoniazid is found in breast milk. If you are or will be breast-feeding while you use PMS-Isoniazid, check with your doctor. Discuss any possible risks to your baby.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Mild stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; chills or fever; dark urine; general feeling of discomfort; increased thirst or urination; joint pain or swelling; loss of appetite; memory problems; mental or mood changes; nausea; seizures; stomach pain or tenderness; symptoms of low vitamin B6 levels (eg, confusion, cracks in the corners of the mouth, irritability, mouth redness or soreness, scaly rash); tingling or numbness in the hands or feet; unusual bruising or bleeding; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.
 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Rare

  • Blurred vision or loss of vision, with or without eye pain
  • convulsions (seizures)
  • fever and sore throat
  • joint pain
  • mental depression
  • mood or other mental changes
  • skin rash
  • unusual bleeding or bruising

More Common

  • Diarrhea
  • stomach pain
Type Small Molecule
Accession Number DB00951  (APRD01055, EXPT01940)
Groups Approved, Investigational
Synonyms
  • 4-pyridinecarbohydrazide
  • INH
  • Isoniazid
  • Isonicotinic acid hydrazide
  • Isonicotinic hydrazide
  • Isonicotinohydrazide
  • Isonicotinoylhydrazide
  • Isonicotinsaeurehydrazid
  • Isonicotinylhydrazine
  • Pyridine-4-carboxylic acid hydrazide
UNII V83O1VOZ8L
CAS number 54-85-3
Weight Average: 137.1393
Monoisotopic: 137.058911861
Chemical Formula C6H7N3O
InChI
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
IUPAC Name
pyridine-4-carbohydrazide
Protein binding

Very low (0-10%)

Toxicity

LD50 100 mg/kg (Human, oral). Adverse reactions include rash, abnormal liver function tests, hepatitis, peripheral neuropathy, mild central nervous system (CNS) effects. In vivo, Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate. Isoniazid also combines with pyridoxal phosphate; high doses interfere with the coenzyme function of the latter.

Half life

Fast acetylators: 0.5 to 1.6 hours. Slow acetylators: 2 to 5 hours.

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