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Paxifor (Brand name: Abilify)

  • $0.55
  • Brand name: Abilify
  • Availability: In Stock
  • Active Ingredient Aripiprazole
Paxifor is an antipsychotic drug to relieve symptoms of schizophrenia and bipolar disorder.
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15 mg
Product name Per Pill Per Pack  
30 pills $1.55 $46.35
60 pills $1.09 $92.71 $65.40
90 pills $0.94 $139.06 $84.45
120 pills $0.86 $185.41 $103.49
180 pills $0.79 $278.12 $141.59
270 pills $0.74 $417.18 $198.72
360 pills $0.71 $556.24 $255.85
10 mg
Product name Per Pill Per Pack  
60 pills $0.91 $54.43
90 pills $0.78 $81.64 $70.53
180 pills $0.66 $163.28 $118.85
270 pills $0.62 $244.92 $167.18
360 pills $0.60 $326.56 $215.53
5 mg
Product name Per Pill Per Pack  
60 pills $0.81 $48.60
90 pills $0.71 $72.90 $63.57
120 pills $0.65 $97.20 $78.54
180 pills $0.60 $145.80 $108.47
270 pills $0.57 $218.70 $153.39
360 pills $0.55 $291.60 $198.29
20 mg
Product name Per Pill Per Pack  
30 pills $2.47 $74.08
60 pills $1.76 $148.15 $105.32
90 pills $1.52 $222.23 $136.58
120 pills $1.40 $296.30 $167.82
180 pills $1.28 $444.46 $230.31
270 pills $1.20 $666.68 $324.05
360 pills $1.16 $888.91 $417.78

Product Description

Common use
Paxifor is an add-on medication used for the treatment of major depressive disorder, schizophrenia, manic and mixed episodes associated with bipolar disorder in adults and children and adolescents and also of irritability associated with autistic disorder in pediatric patients. The mechanism of action of Paxifor is unknown. It shows partial agonism at the D2 receptor, it is also a partial agonist at the 5-HT1A receptor, and also displays an antagonist profile at the 5-HT2A receptor. It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.

Dosage and direction

Take Paxifor once a day with or without food. The usual starting dose is 10 or 15 mg, later the dose may be increased to achieve the desired effect.

Precautions

This medication was not approved for use in elderly people with psychosis related to dementia-related psychosis due to the risk of death. Antidepressants increase suicidal thoughts or behaviors in some adolescents especially if the dose is changed or during first period of treatment. Paxifor was not approved for use in pediatric patients with depression. As Paxifor is able to impair judgment, thinking, or motor skills do not use is during operating hazardous machinery, including automobiles if you are not sure that Paxifor therapy does not affect you adversely. Inform your doctor if you are pregnant, plan to become pregnant or breastfeeding before taking this medication. Avoid drinking any alcoholic beverages during treatment. Avoid overheating and dehydration. Hyperglycemia, or elevated blood sugar, may occur when taking Paxifor. If you have diabetes mellitus, monitor your blood sugar levels regularly.

Contraindications

Breastfeeding, hypersensitivity.

Possible side effects

Most common adverse effects include nausea, vomiting, constipation, headache, dizziness, nervousness, sleeplessness, restlessness, tremors, cough, headache, insomnia, lightheadedness, rash, runny nose, weakness, and weight gain. More serious and rare adverse reactions such as an increased risk of stroke and ministroke; neuroleptic malignant syndrome (NMS) which symptoms include fever, rigid muscles, confusion; tardive dyskinesia (TD) which symptoms include uncontrolled and abnormal movements of body parts.

Drug interaction

Inform your doctor about all prescribed and over-the-counter medications and herbal products you are taking and especially if you use alcohol, blood pressure drugs, carbamazepine, fluoxetine, ketoconazole, paroxetine, and quinidine.
Carbamazepine (Tegretol) decreases the levels of Paxiforole in the body stimulating the liver enzymes such as CYP3A4. Similar influence on Paxifor is shown by phenytoin (Dilantin), rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate), and phenobarbital. Blocking of CYP3A4 by Ketoconazole (Nizoral) increases the amount of Paxifor in the body. Other drugs with similar action are: itraconazole (Sporanox), fluconazole (Diflucan), voriconazole (Vfend), cimetidine (Tagamet), verapamil (Calan, Isoptin), diltiazem (Cardizem, Dilacor), erythromycin, clarithromycin (Biaxin), nefazodone (Serzone), ritonavir (Norvir), saquinavir (Invirase), nelfinavir (Viracept), indinavir (Crixivan), and grapefruit juice. Their action is not well studied though.
Quinidine (Quinaglute, Quinidex) inhibits another liver enzyme known as CYP2D6 and also is able to increase the levels of Paxifor. Other medicines with similar action are fluoxetine (Prozac) and paroxetine (Paxil). Paxifor may dangerously increase blood sugar levels in patients with diabetes.


Missed dose

Paxifor is taken once daily, so take the missed dose as soon as you remember. If the next dose is within 12 hours, do not take the missed dose and resume your normal dosing schedule. Never double the dose of this medication.

Overdose

Common adverse reactions include vomiting, somnolence, and tremor. Other clinically important signs and symptoms observed are acidosis, aggression, aspartate aminotransferase increased, atrial fibrillation, bradycardia, coma, confusional state, convulsion, blood creatine phosphokinase increased, depressed level of consciousness, hypertension, hypokalemia, hypotension, lethargy, loss of consciousness, QRS complex prolonged, QT prolonged, pneumonia aspiration, respiratory arrest, status epilepticus, and tachycardia.

Storage

Store at room temperature in a tight dry container out of reach of children and pets. Do not use after expiration term.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Rare

  • High fever
  • high or low blood pressure
  • increased sweating
  • lip smacking or puckering
  • loss of bladder control
  • muscle spasm or jerking of all extremities
  • puffing of the cheeks
  • rapid or worm-like movements of the tongue
  • seizures
  • severe muscle stiffness
  • sudden loss of consciousness
  • tiredness
  • uncontrolled chewing movements
  • uncontrolled movements of the arms and legs
  • unusually pale skin

More Common

  • Difficulty with speaking
  • drooling
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • restlessness
  • shuffling walk
  • stiffness of the limbs
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • Anxiety
  • belching
  • blurred vision
  • difficulty having a bowel movement
  • dry mouth
  • fear
  • fever
  • heartburn
  • hyperventilation
  • inability to sit still
  • indigestion
  • irritability
  • lightheadedness
  • need to keep moving
  • nervousness
  • rash
  • runny nose
  • shaking
  • sore throat
  • stomach discomfort, upset, or pain
  • trouble sleeping
  • weight gain

Less Common

  • Blurred vision
  • dizziness
  • headache
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • sticking out the tongue
  • trouble with breathing or swallowing
  • unusual facial expressions
  • Accidental injury
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • congestion
  • coughing
  • difficulty with moving
  • dryness or soreness of the throat
  • hoarseness
  • increased appetite
  • increased salivation
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • rapid weight gain
  • sneezing
  • stuffy nose
  • swollen joints
  • tender, swollen glands in the neck
  • tingling of the hands or feet
  • tremor
  • unusual weight gain or loss
  • voice changes

Incidence Not Known

  • Hives or welts, itching, or skin rash
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • redness of the skin
  • tightness in the chest
  • unusual tiredness or weakness
Type Small Molecule
Accession Number DB01238  (APRD00638)
Groups Approved, Investigational
Synonyms
  • Abilitat
  • Aripiprazol
  • Aripiprazole
  • Aripiprazolum
  • OPC 31
UNII 82VFR53I78
CAS number 129722-12-9
Weight Average: 448.385
Monoisotopic: 447.148032537
Chemical Formula C23H27Cl2N3O2
InChI
InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
IUPAC Name
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one
Protein binding

>99%

Toxicity Not Available
Half life

75-146 hours

Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:

  • Algiers
  • Oran
  • Constantine
  • Annaba
  • Blida
  • Batna
  • Djelfa
  • Sétif
  • Sidi Bel Abbès
  • Biskra
  • Tébessa
  • El Oued
  • Skikda
  • Tiaret
  • Béjaïa
  • Tlemcen
  • Ouargla
  • Béchar
  • Mostaganem
  • Bordj Bou Arréridj
  • Chlef
  • Souk Ahras
  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou