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Pertium (Brand name: Bystolic)

  • $0.75
  • Brand name: Bystolic
  • Availability: In Stock
  • Active Ingredient Nebivolol
Pertium (Nebivolol) is a beta-blocker that works by slowing down the heart and decreasing the amount of blood it pumps out.
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5 mg
Product name Per Pill Per Pack  
30 pills $1.63 $48.79
60 pills $1.28 $97.58 $76.73
90 pills $1.16 $146.38 $104.66
120 pills $1.10 $195.17 $132.59
180 pills $1.05 $292.75 $188.46
270 pills $1.01 $439.13 $272.27
2.5 mg
Product name Per Pill Per Pack  
30 pills $1.23 $36.94
60 pills $0.97 $73.87 $58.16
90 pills $0.88 $110.81 $79.38
120 pills $0.84 $147.74 $100.60
180 pills $0.79 $221.62 $143.05
270 pills $0.77 $332.42 $206.71
360 pills $0.75 $443.23 $270.36

Drug Name

Pertium (Nebivolol) 

Drug Uses

Pertium is used for treating high blood pressure. It may also be used for other conditions as determined by your doctor. 

How to use

Use Pertium as directed by your doctor. 
Take Pertium by mouth with or without food.
Take Pertium on a regular schedule to get the most benefit from it. Taking Pertium at the same time each day will help you remember to take it.
Continue to take Pertium even if you feel well. Do not miss any doses.
Do not suddenly stop taking Pertium without first talking with your doctor. You may have an increased risk of side effects (e.g., chest pain, irregular heartbeat). If you need to stop Pertium or add a new medicine, your doctor may need to gradually lower your dose.
Ask your health care provider any questions you may have about how to use Pertium.

Drug Class and Mechanism

Pertium is a beta-blocker. It works by slowing down the heart and decreasing the amount of blood it pumps out. This helps to decrease blood pressure, helps the heart pump more efficiently, and reduces the workload on the heart. 

Missed Dose

If you miss a dose of Pertium and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. 
Storage

Store Pertium at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Pertium out of the reach of children and away from pets.

Warnings/Precautions

Do not use Pertium if: 
you are allergic to any ingredient in Pertium;
you have moderate to severe heart block, uncontrolled heart failure, shock caused by serious heart problems, very slow heartbeat, or very low blood pressure after a heart attack;
you have asthma or Raynaud syndrome;
you have severe liver problems;
the patient is a child with diabetes or heart failure;
you are taking mibefradil.
Contact your doctor or health care provider right away if any of these apply to you.

Important:

Pertium may cause drowsiness, dizziness, lightheadedness, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use Pertium with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Check with your doctor before you drink alcohol while you are taking Pertium ; it may increase the risk of Pertium 's side effects.
Do not take more than the recommended dose without checking with your doctor.
Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
Tell your doctor or dentist that you take Pertium before you receive any medical or dental care, emergency care, or surgery.
If you have a history of any severe allergic reaction, talk with your doctor. You may be at risk for an even more severe allergic reaction if you come into contact with the substance that caused your allergy. Some medicines used to treat severe allergies may also not work as well while you are using Pertium.
Pertium may lower your blood sugar levels. This is most likely to happen in infants and children, or in patients who have diabetes or kidney problems. It may also occur after prolonged physical activity or during fasting. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens.
Diabetes patients - Pertium may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Pertium may interfere with certain lab tests, including the glaucoma screening test and dobutamine stress echocardiography. Be sure your doctor and lab personnel know you are taking Pertium.
Lab tests, including blood pressure, heart function, kidney function, and blood cholesterol levels, may be performed while you use Pertium. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Pertium with caution in the elderly; they may be more sensitive to its effects.
Pertium should not be used in children; safety and effectiveness in children have not been confirmed.
Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Pertium while you are pregnant. It is not known if Pertium is found in breast milk. Do not breast-feed while taking Pertium.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome: 
dizziness; fatigue; headache; nausea; stomach pain; trouble sleeping.
Seek medical attention right away if any of these severe side effects occur:
severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or tightness; fainting; mental or mood changes; numbness or tingling of the hands; persistent or severe vision changes; red, swollen, blistered, or peeling skin; severe dizziness; shortness of breath or wheezing; sudden, unusual weight gain; swelling of the hands, ankles, or feet; unusual bruising or bleeding; unusual tiredness or weakness; unusually slow or irregular heartbeat; very cold or blue fingers or toes.

More Information

Pertium is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

More Common

  • Mild headache

Less Common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or discomfort
  • difficult or labored breathing
  • lightheadedness, dizziness, or fainting
  • rapid weight gain
  • shortness of breath
  • slow or irregular heartbeat
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • wheezing
  • Diarrhea
  • rash
  • sleeplessness
  • trouble sleeping
  • unable to sleep
Type Small Molecule
Accession Number DB04861
Groups Approved, Investigational
Synonyms
  • 1,1'-[Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol
  • 1,1'-Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2,2'-iminodiethanol
  • alpha,alpha'-(iminobismethylene)bis-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
  • alpha,alpha'-(iminodimethylene)bis-(6-fluoro-2-chromanmethanol)
  • Narbivolol
  • Nebivololum
UNII 030Y90569U
CAS number 118457-14-0
Weight Average: 405.435
Monoisotopic: 405.175164703
Chemical Formula C22H25F2NO4
InChI
InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2
IUPAC Name
1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-{[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino}ethan-1-ol
Protein binding

98%

Toxicity

The most common signs and symptoms associated with nebivolol overdosage are bradycardia and hypotension. Other important adverse events reported with nebivolol overdose include cardiac failure, dizziness, hypoglycemia, fatigue and vomiting. Other adverse events associated with β-blocker overdose include bronchospasm and heart block. The largest known ingestion of nebivolol worldwide involved a patient who ingested up to 500 mg of nebivolol along with several 100 mg tablets of acetylsalicylic acid in a suicide attempt. The patient experienced hyperhydrosis, pallor, depressed level of consciousness, hypokinesia, hypotension, sinus bradycardia, hypoglycemia, hypokalemia, respiratory failure and vomiting. The patient recovered.

Half life

10 hours

Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:

  • Algiers
  • Oran
  • Constantine
  • Annaba
  • Blida
  • Batna
  • Djelfa
  • Sétif
  • Sidi Bel Abbès
  • Biskra
  • Tébessa
  • El Oued
  • Skikda
  • Tiaret
  • Béjaïa
  • Tlemcen
  • Ouargla
  • Béchar
  • Mostaganem
  • Bordj Bou Arréridj
  • Chlef
  • Souk Ahras
  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou