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PTA-D (Brand name: Protonix)
Apton Apazol Anulacid Anesteloc Anagastra Acipan Aciban Acernix Aciban Aciban-DSR Acida Acidwell Acilib Acillect Acillect-DSR Acipan Acipan Control Acipan Stop Acrid Amphoter Anesteloc Antaxid Antopral Anulacid Anxel Apo-Pantoprazole Armcid Arthopan Asoprazole Asoprazole-D Aspen Pantoprazole Aurizol-P Abbott-Pantoprazole Acido-X Acidrol Acilibre Alapanzol Amavita Pantoprazol Anagastra Anagastra Euromedicines Apazol Apo-Panto Appryo Aptizole Apton Aspan Awamed PTA-D
|Product name||Per Pill||Savings||Per Pack|
|90 pills||$0.80||$11.74||$83.83 $72.09|
|120 pills||$0.74||$23.47||$111.77 $88.30|
|180 pills||$0.67||$46.94||$167.65 $120.71|
|270 pills||$0.63||$82.16||$251.48 $169.32|
|360 pills||$0.61||$117.36||$335.30 $217.94|
|Product name||Per Pill||Savings||Per Pack|
|90 pills||$0.50||$7.89||$53.33 $45.43|
|120 pills||$0.46||$15.78||$71.10 $55.32|
|180 pills||$0.42||$31.57||$106.65 $75.08|
|270 pills||$0.39||$55.24||$159.98 $104.73|
|360 pills||$0.37||$78.91||$213.30 $134.39|
PTA-D accumulates in the tubules of parietal cells of the stomach and transforms into its active form that interacts with the H+-K+-ATP-ase. PTA-D inhibits this enzyme and prevents transfer of hydrogen ions from the parietal cells into the stomach cavity this way blocking the final stage of hydrochloric acid secretion. PTA-D inhibits basal and stimulated (regardless type of a stimuli - acetylcholine, histamine, gastrin) secretion of hydrochloric acid. This medication is used to treat acute stage of duodenal or gastric ulcers, including those caused by treatment with anti-inflammatory non-steroid medications, gastroesophageal reflux disease (moderate and severe); Zollinger-Ellison syndrome, eradication of H. pylori in patients with a peptic ulcer to reduce the frequency of relapses.
Dosage and directions
Take exactly as administered by your doctor. Usually for patients with stomach or duodenum ulcers, gastroesophageal reflux disease PTA-D is recommended as 40 mg daily dose. Treatment continues mostly during four weeks. Combined treatment with antibiotics (amoxicillin and clarithromycin) directed eradicate H. pylori in patients with ulcers in stomach and duodenum requires PTA-D 40 mg daily divided in two doses: take one tablet before breakfast and before supper, do not chew or crash it, eat it whole with a glass of water. In case you purchased PTA-D oral granules take them mixed only with applesauce or apple juice to make swallowing easy. Do not use any other type of liquid or soft food for it. Do not crush, chew, or break a delayed-release tablet.
Some conditions require longterm treatment with PTA-D. This medication is known to provoke cancer in animals but it was not tested for cancer in humans. It also causes deficit of vitamin B-12. Symptoms of a vitamin B-12 shortage may develop slowly and include pale skin, weakness, tired feeling, shortness of breath, and a fast heart rate. Discuss with your doctor if you are pregnant, plan to become pregnant or breastfeeding as there is no evidence on influence of this drug on an unborn baby.
Hypersensitivity, hepatitis and cirrhosis combined with severe liver failure.
Possible side effect
Most common side effects may appear as diarrhea, nausea, vomiting, constipation, rash and headaches, dizziness, nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention. Allergic reaction is also possible: hives, swelling of face and tongue, rash.
PTA-D is able to decrease pH-dependent absorption of ketoconazole and other medications. PTA-D also increases the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduction of ketoconazole effectiveness or increase of digoxin toxicity, respectively.
If you missed a dose take it the soonest. If it is almost time for your next dose, just skip it and return to your regular dosage schedule. Never double dose of this medication to compensate the missed dose.
This medication is not expected to cause life threating side effect if it was overdosed. If you suppose that took too much of it, seek for immediate medical help.
Store at room temperature between 15-30 C (59-86 F) away from light and moisture, kids and pets.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:
- Abdominal or stomach pain
- blurred vision
- dry mouth
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- troubled breathing
- unexplained weight loss
- bloated or full feeling
- excess air or gas in the stomach or intestines
- passing gas
- trouble sleeping
Incidence Not Known
- Absence of or decrease in body movements
- blistering, peeling, or loosening of the skin
- bloody or cloudy urine
- bloody, black, or tarry stools
- blurred vision
- clay-colored stools
- continuous ringing or buzzing or other unexplained noise in the ears
- dark-colored urine
- decreased vision
- difficulty with speaking
- difficulty with swallowing
- dizziness or lightheadedness
- fast heartbeat
- feeling of constant movement of self or surroundings
- general feeling of tiredness or weakness
- greatly decreased frequency of urination or amount of urine
- hearing loss
- high fever
- hives, itching, or skin rash
- joint pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- loss of appetite
- mood or mental changes
- muscle cramps
- muscle pain or stiffness
- muscle spasms (tetany) or twitching
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pale skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- sensation of spinning
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach pain, continuing
- swelling of the feet or lower legs
- swollen glands
- tightness in the chest
- unexplained bleeding or bruising
- unpleasant breath odor
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
- Increased watering of the mouth
|Accession Number||DB00213 (APRD00073)|
Single intravenous doses of pantoprazole at 378, 230, and 266 mg/kg (38, 46, and 177 times the recommended human dose based on body surface area) were lethal to mice, rats and dogs, respectively. The symptoms of toxicity included hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor. There is limited experience regarding cases of human overdosage, and treatment should be symptomatic and supportive.
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- Sidi Bel Abbès
- El Oued
- Bordj Bou Arréridj
- Souk Ahras
- El Eulma
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- Tizi Ouzou