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Protocent-DSR (Brand name: Protonix)

  • $0.37
  • Brand name: Protonix
  • Availability: In Stock
  • Active Ingredient Pantoprazole
Protocent-DSR decreases a ruining effect of stomach acid on mucous of esophagus and used to heal erosive esophagitis.
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40 mg
Product name Per Pill Per Pack  
60 pills $0.93 $55.88
90 pills $0.80 $83.83 $72.09
120 pills $0.74 $111.77 $88.30
180 pills $0.67 $167.65 $120.71
270 pills $0.63 $251.48 $169.32
360 pills $0.61 $335.30 $217.94
20 mg
Product name Per Pill Per Pack  
60 pills $0.59 $35.55
90 pills $0.50 $53.33 $45.43
120 pills $0.46 $71.10 $55.32
180 pills $0.42 $106.65 $75.08
270 pills $0.39 $159.98 $104.73
360 pills $0.37 $213.30 $134.39

Product Description

Common use

Protocent-DSR accumulates in the tubules of parietal cells of the stomach and transforms into its active form that  interacts with the H+-K+-ATP-ase. Protocent-DSR inhibits this enzyme and prevents transfer of hydrogen ions from the parietal cells into the stomach cavity this way blocking the final stage of hydrochloric acid secretion. Protocent-DSR inhibits basal and stimulated (regardless type of a stimuli - acetylcholine, histamine, gastrin) secretion of hydrochloric acid. This medication is used to treat acute stage of duodenal or gastric ulcers, including those caused by treatment with anti-inflammatory non-steroid medications, gastroesophageal reflux disease (moderate and severe); Zollinger-Ellison syndrome, eradication of H. pylori in patients with a peptic ulcer to reduce the frequency of relapses.

Dosage and directions

Take exactly as administered by your doctor. Usually for patients with stomach or duodenum ulcers, gastroesophageal reflux disease Protocent-DSR is recommended as 40 mg daily dose. Treatment continues mostly during four weeks. Combined treatment with antibiotics (amoxicillin and clarithromycin) directed eradicate H. pylori in patients with ulcers in stomach and duodenum requires Protocent-DSR 40 mg daily divided in two doses: take one tablet before breakfast and before supper, do not chew or crash it, eat it whole with a glass of water. In case you purchased Protocent-DSR oral granules take them mixed only with applesauce or apple juice to make swallowing easy. Do not use any other type of liquid or soft food for it. Do not crush, chew, or break a delayed-release tablet.

Precautions

Some conditions require longterm treatment with Protocent-DSR. This medication is known to provoke cancer in animals but it was not tested for cancer in humans. It also causes deficit of vitamin B-12. Symptoms of a vitamin B-12 shortage may develop slowly and include pale skin, weakness, tired feeling, shortness of breath, and a fast heart rate. Discuss with your doctor if you are pregnant, plan to become pregnant or breastfeeding as there is no evidence on influence of this drug on an unborn baby.

Contraindications

Hypersensitivity, hepatitis and cirrhosis combined with severe liver failure.

Possible side effect

Most common side effects may appear as diarrhea, nausea, vomiting, constipation, rash and headaches, dizziness, nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention. Allergic reaction is also possible: hives, swelling of face and tongue, rash.

Drug interaction

Protocent-DSR is able to decrease pH-dependent absorption of ketoconazole and other medications. Protocent-DSR also increases the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduction of ketoconazole effectiveness or increase of digoxin toxicity, respectively.

Missed dose

If you missed a dose take it the soonest. If it is almost time for your next dose, just skip it and return to your regular dosage schedule. Never double dose of this medication to compensate the missed dose.

Overdose

This medication is not expected to cause life threating side effect if it was overdosed. If you suppose that took too much of it, seek for immediate medical help.

Storage

Store at room temperature between 15-30 C (59-86 F) away from light and moisture, kids and pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Less Common

  • Abdominal or stomach pain
  • blurred vision
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • nausea
  • sweating
  • troubled breathing
  • unexplained weight loss
  • vomiting
  • Belching
  • bloated or full feeling
  • excess air or gas in the stomach or intestines
  • passing gas
  • trouble sleeping

Incidence Not Known

  • Absence of or decrease in body movements
  • blindness
  • blistering, peeling, or loosening of the skin
  • bloating
  • bloody or cloudy urine
  • bloody, black, or tarry stools
  • blurred vision
  • chills
  • clay-colored stools
  • constipation
  • continuous ringing or buzzing or other unexplained noise in the ears
  • cough
  • dark-colored urine
  • decreased vision
  • diarrhea
  • difficulty with speaking
  • difficulty with swallowing
  • dizziness or lightheadedness
  • drowsiness
  • fast heartbeat
  • feeling of constant movement of self or surroundings
  • fever
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • hearing loss
  • high fever
  • hives, itching, or skin rash
  • indigestion
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • mood or mental changes
  • muscle cramps
  • muscle pain or stiffness
  • muscle spasms (tetany) or twitching
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • sensation of spinning
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain, continuing
  • swelling of the feet or lower legs
  • swollen glands
  • tightness in the chest
  • trembling
  • unexplained bleeding or bruising
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin
  • Increased watering of the mouth
Type Small Molecule
Accession Number DB00213  (APRD00073)
Groups Approved
Synonyms
  • Pantoprazol
  • Pantoprazolum
UNII D8TST4O562
CAS number 102625-70-7
Weight Average: 383.37
Monoisotopic: 383.075133083
Chemical Formula C16H15F2N3O4S
InChI
InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
IUPAC Name
6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole
Protein binding

98%

Toxicity

Single intravenous doses of pantoprazole at 378, 230, and 266 mg/kg (38, 46, and 177 times the recommended human dose based on body surface area) were lethal to mice, rats and dogs, respectively. The symptoms of toxicity included hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor. There is limited experience regarding cases of human overdosage, and treatment should be symptomatic and supportive.

Half life

1 hour

Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:

  • Algiers
  • Oran
  • Constantine
  • Annaba
  • Blida
  • Batna
  • Djelfa
  • Sétif
  • Sidi Bel Abbès
  • Biskra
  • Tébessa
  • El Oued
  • Skikda
  • Tiaret
  • Béjaïa
  • Tlemcen
  • Ouargla
  • Béchar
  • Mostaganem
  • Bordj Bou Arréridj
  • Chlef
  • Souk Ahras
  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou