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PAT-rabeprazole (Brand name: Aciphex)
- $0.56
| Product name | Per Pill | Savings | Per Pack | |
|---|---|---|---|---|
| 30 pills | $1.15 | $34.43 | ||
| 60 pills | $0.94 | $12.40 | $68.86 $56.46 | |
| 90 pills | $0.87 | $24.79 | $103.28 $78.50 | |
| 120 pills | $0.84 | $37.19 | $137.71 $100.52 | |
| 180 pills | $0.80 | $61.97 | $206.57 $144.59 | |
| 270 pills | $0.78 | $99.14 | $309.85 $210.71 | |
| 360 pills | $0.77 | $136.33 | $413.14 $276.80 |
| Product name | Per Pill | Savings | Per Pack | |
|---|---|---|---|---|
| 60 pills | $0.86 | $51.35 | ||
| 90 pills | $0.74 | $10.48 | $77.03 $66.56 | |
| 120 pills | $0.68 | $20.95 | $102.71 $81.76 | |
| 180 pills | $0.62 | $41.90 | $154.06 $112.16 | |
| 270 pills | $0.58 | $73.33 | $231.09 $157.76 | |
| 360 pills | $0.56 | $104.76 | $308.12 $203.36 |
Product Description
Common use
PAT-rabeprazole is an antiulcer medication which inhibits a proton pump (PPIs) and blocks the production of acid by the stomach. Biochemically it blocks the (H+,K+)-ATPase enzyme system hereby inhibiting the final stage of hydrochloric acid production. After peroral intake of PAT-rabeprazole antisecretorial effect is reached during one hour and is maximal in 2-4 hours. This medication is used to treat ulcers in stomach, Zollinger-Ellison syndrome, gastroesophageal reflux disease, to eradicate Helicobacter pylori in patients with ulcers in stomach or chronic gastritis.
Dosage and directions
Dosage should be administered by your doctor depending on your condition. Usually in patients with an acute duodenal ulcer and c it is recommended to take 1 tab (20 mg) in the morning one time a day during 4-6 weeks. When treating H. pylori infection, PAT-rabeprazole may be needed for only a week. Follow all recommendations of your doctor and do not take this drug in larger amounts than it was prescribed to you. Tablets should be swallowed whole. Do not crush, split or chew them. Take PAT-rabeprazole with or without meals with a big glass of water since food has little effect on its absorption.
Precautions
Notify your doctor if you have a severe liver disease, cancer of stomach before taking this drug. The use of PAT-rabeprazole in children is not recommended. It is not expected to be harmful to an unborn baby, though inform your doctor if you are pregnant or breastfeeding. Some conditions are treated with a combination of PAT-rabeprazole and antibiotics, so to achieve the maximal effect from treatment, use all of your medications as directed by your doctor.
Contraindications
Pregnancy, breastfeeding, hypersensitivity to PAT-rabeprazole or a substituted benzimidazoles: omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (PAT-rabeprazole), and esomeprazole (Nexium).
Possible side effects
Together with symptoms of allergy (hives, rash, swelling of tongue and face) the following side effects may occur: headache, dizziness, dry mouth, upset stomach or diarrhea, constipation, insomnia, nervousness, rash, or itching. Contact your doctor for help if any of the listed side effects is severe or persistent.
Drug interaction
Co-administration with the medications which absorption depends on acidity of the stomach causes interaction of medications. PAT-rabeprazole and other PPIs reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin) causing reduction of effectiveness of the former and increase of toxicity of the latter.
Missed dose
If you missed a dose take the medication as soon as you remember. If it is almost time for your next dose just skip its intake and return to your regular schedule.
Overdose
Symptoms of PAT-rabeprazole overdose are unknown. If you consider that you took too much of the drug seek emergency medical attention.
Storage
Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets.
Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:
Rare
- Bloody urine
- continuing ulcers or sores in the mouth
- convulsions (seizures)
- difficulty with breathing
- sore throat
- unusual bleeding or bruising
- unusual tiredness or weakness
More Common
- Bad, unusual, or unpleasant (after) taste
- change in taste
Less Common
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- cough or hoarseness
- dark urine
- dry mouth
- fever or chills
- general tiredness and weakness
- light-colored stools
- lower back or side pain
- nausea and vomiting
- painful or difficult urination
- rapid weight gain
- tingling of the hands or feet
- unusual weight gain or loss
- yellow eyes and skin
Incidence Not Known
- Back, leg, or stomach pains
- bleeding gums
- blood in the urine or stools
- bloody, black, or tarry stools
- change in consciousness
- clay-colored stools
- cloudy urine
- confusion about identity, place, person, and time
- continuing nausea or vomiting
- difficulty with swallowing
- dizziness
- drowsiness
- fast heartbeat
- general body swelling
- general feeling of tiredness or weakness
- greatly decreased frequency of urination or amount of urine
- headache
- high fever
- hives, itching, or skin rash
- holding false beliefs that cannot be changed by fact
- increase in the frequency of seizures
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- loss of consciousness
- mood or mental changes
- muscle cramps
- muscle pain or stiffness
- muscle spasms (tetany) or twitching
- no blood pressure
- no breathing
- no pulse
- nosebleeds
- pale skin
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- seeing, hearing, or feeling things that are not there
- skin blisters
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- tightness in the chest
- trembling
- unpleasant breath odor
- unusual excitement, nervousness, or restlessness
- vomiting of blood
- Blistering, peeling, or loosening of the skin
- red, irritated eyes
- red skin lesions, often with a purple center
| Type | Small Molecule |
| Accession Number | DB01129 (APRD01212) |
| Groups | Approved, Investigational |
| Synonyms |
|
| UNII | 32828355LL |
| CAS number | 117976-89-3 |
| Weight | Average: 359.443 Monoisotopic: 359.130362243 |
| Chemical Formula | C18H21N3O3S |
| InChI | InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21) |
| IUPAC Name | 2-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methanesulfinyl}-1H-1,3-benzodiazole |
| Protein binding | 96.3% (bound to human plasma proteins) |
| Toxicity | Not Available |
| Half life | 1-2 hours (in plasma) |
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