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Predial Plus (Brand name: Metformin)
Anglucid Amaryl m Aglurab Aglumet Adimet Adecco Actos Met Adglim-M Aglikem Alexodiab Amaryl m Amaryl M Forte Amaryl M SR Amophage Andibet Anglucid Anhe Asegur Asoformin Asoformin-P Asoride-M Avandamet Accord Metformin Actomeg ActoPlus met XR Actos M Actosmet Adecco Adimet Adride-M Agimfor Aglumet Aglurab Amaryl Combi Amaryl XM Ammiformin Andm Anformin Ankomin Ansures Ansures ER Antigluco Anxofin Anxoken Apo-Metformin Aromet Arrow Metformine HCL Asformin Austell-Metformin Avamina Predial Plus
|Product name||Per Pill||Savings||Per Pack|
|90 pills||$0.66||$7.54||$67.33 $59.79|
|120 pills||$0.62||$15.08||$89.77 $74.69|
|180 pills||$0.58||$30.17||$134.66 $104.49|
|270 pills||$0.55||$52.79||$201.99 $149.20|
|360 pills||$0.54||$75.38||$269.32 $193.93|
|Product name||Per Pill||Savings||Per Pack|
|180 pills||$0.30||$13.00||$67.16 $54.16|
|360 pills||$0.26||$38.95||$134.32 $95.36|
Predial Plus is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other anti-diabetic medicines.
How to use
Use Predial Plus as directed by your doctor.
Take Predial Plus by mouth with food.
Take Predial Plus on a regular schedule to get the most benefit from it. Taking Predial Plus at the same time each day will help you remember to take it.
Continue taking Predial Plus even if you feel good. Do not miss any doses.
Ask your health care provider any questions you may have about its usage.
Drug Class and Mechanism
Predial Plus is a biguanide antidiabetic. It works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.
If you miss a dose of Predial Plus and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Store Predial Plus between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Predial Plus out of the reach of children and away from pets.
Do not use Predial Plus if:
you are allergic to any ingredient in Predial Plus;
you have congestive heart failure that is treated by medicine;
you have a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (e.g., diabetic ketoacidosis), or severe dehydration;
you have had a stroke or a recent heart attack, or you are in shock;
you are 80 years old or older and have not had a kidney function test;
you will be having surgery or certain lab procedures.
Contact your doctor or health care provider right away if any of these apply to you.
Dizziness may occur while you are taking Predial Plus. This effect may be worse if you take it with alcohol or certain medicines. Use Predial Plus with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Follow the diet and exercise program given to you by your health care provider.
Do not drink large amounts of alcohol while you use Predial Plus. Talk to your doctor or health care provider before you drink alcohol while you use Predial Plus.
Tell your doctor or dentist that you take Predial Plus before you receive any medical or dental care, emergency care, or surgery.
Be careful not to become dehydrated, especially during hot weather or while you are being active. Dehydration may increase the risk of Predial Plus 's side effects.
Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Predial Plus exactly as prescribed, tell your doctor.
This medicine does not usually lower your blood sugar levels. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take Predial Plus along with certain medicines for diabetes (e.g., sulfonylureas, insulin). It is a good idea to carry a reliable source of glucose (e.g., tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
Fever, infection, injury, or surgery may increase your risk for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away.
Predial Plus may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis.
Lab tests, including kidney function, fasting blood glucose, hemoglobin A1c, and blood counts, may be performed while you use Predial Plus. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Predial Plus with caution in the elderly; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.
Predial Plus should not be used in children younger than 10 years old; safety and effectiveness in these children have not been confirmed.
Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Predial Plus while you are pregnant. It is not known if Predial Plus is found in breast milk. Do not breast-feed while taking Predial Plus.
Possible Side Effects
Check with your doctor if any of these most common side effects persist or become bothersome:
Diarrhea; gas; headache; indigestion; nausea; stomach upset; temporary metallic taste; vomiting.
Seek medical attention right away if any of these severe side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; dizziness or lightheadedness; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness.
If you have any questions about Hydrochlorothiazide, please talk with your doctor, pharmacist, or other health care provider.
Predial Plus is to be used only by the patient for whom it is prescribed. Do not share it with other people.
Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:
- Behavior change similar to being drunk
- difficulty with concentrating
- lack or loss of strength
- restless sleep
- unusual sleepiness
- Abdominal or stomach discomfort
- cough or hoarseness
- decreased appetite
- fast or shallow breathing
- fever or chills
- general feeling of discomfort
- lower back or side pain
- muscle pain or cramping
- painful or difficult urination
- Acid or sour stomach
- excess air or gas in the stomach or intestines
- full feeling
- loss of appetite
- metallic taste in the mouth
- passing of gas
- stomach upset or pain
- weight loss
- blurred vision
- chest discomfort
- cold sweats
- cool, pale skin
- difficult or labored breathing
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling of warmth
- increased hunger
- increased sweating
- redness of the face, neck, arms, and occasionally, upper chest
- shortness of breath
- slurred speech
- tightness in the chest
- unusual tiredness or weakness
- Abnormal stools
- bad, unusual, or unpleasant (after) taste
- change in taste
- difficulty with moving
- discoloration of the fingernails or toenails
- flu-like symptoms
- joint pain
- metallic taste in mouth
- runny nose
- stuffy nose
- swollen joints
|Accession Number||DB00331 (APRD01099)|
Metformin is negligibly bound to plasma proteins.
Acute oral toxicity (LD50): 350 mg/kg Rabbit. It would be expected that adverse reactions of a more intense character including epigastric discomfort, nausea, and vomiting followed by diarrhea, drowsiness, weakness, dizziness, malaise and headache might be seen.
6.2 hours. Duration of action is 8-12 hours.
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