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Pharmahof Gllizide (Brand name: Glucotrol XL)

  • $0.33
  • Brand name: Glucotrol XL
  • Availability: In Stock
  • Active Ingredient Glipizide
Glucotrol Xl is sulfonylurea class of drugs, a drug used to treat type 2 of diabetes.
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10 mg
Product name Per Pill Per Pack  
60 pills $0.60 $35.96
90 pills $0.49 $53.94 $44.23
120 pills $0.44 $71.92 $52.50
180 pills $0.38 $107.87 $69.03
270 pills $0.35 $161.81 $93.85
360 pills $0.33 $215.75 $118.66

Product Description

Common use

Glipizide is used to treat type 2 of diabetes and belongs to sulfonylurea class of drugs together with glimepiride (Amaryl), glyburide (Micronase, Diabeta), tolbutamide (Orinase) and tolazamide (Tolinase). It stimulates insulin secretion by beta-cells of pancreas.

Dosage and direction

Do not change your dose of Glipizide without first talking to your doctor. A starting dose for immediate release tablets is 5 mg which should be taken 30 minutes before a meal. The maximum dose is 40 mg daily. Maximum dose of extended release tablets should not exceed 20 mg daily. Take it with a full glass of water before a meal. The best result of treatment is achieved when this medication is taken on a regular basis.

Precautions

Treatment with Glipizide may increase the risk of death from cardiovascular disease. Avoid drinking alcoholic beverages as it lowers blood sugar. Do not chew, divide, or crush extended release tablets of Glipizide, swallow them whole.

Contraindications

Hypersensitivity, insulin-dependent diabetes mellitus (juvenile diabetes, diabetes, accompanied by ketoacidosis or precoma) severe kidney or liver failure, stenosis of the gastrointestinal tract, infancy.

Side effects

Besides signs of allergy (hives, rash, swelling of face and tongue) in some patients other symptoms are described: headache, dizziness, diarrhea, gas, hepatitis, jaundice, and a low sodium concentration.

Drug interaction

Alcohol delays effects of Glipizide by slowing its absorption. Glipizide should be administered 1-2 hours before cholestyramine as the latter affects its absorption. Fluconazole (Diflucan) increases absorption and effectiveness of Glipizide. Medications which lower and rise blood sugar are able to change Glipizide effect: aspirin or another salicylate, nonsteroidal anti-inflammatory drugs, sulfa-based drugs such as sulfamethoxazole-trimethoprim (Bactrim, Septra), MAO- inhibitors, beta-blockers such as propranolol (Inderal), thiazide diuretics, steroid medicines such as prednisone (Deltasone, Orasone),estrogens, corticosteroids, thyroid medicines, phenothiazines such as chlorpromazine (Thorazine), niacin, phenytoin, and calcium channel blocking drugs.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or time for your next dose is in a short while. Do not take double doses of this medication or extra doses of it. Take your usual dose next day in the same regular time.

Overdose

Symptoms of Glipizide overdose are ones of low blood sugar: hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma. If you experience one of them or any unusual symptoms call your doctor immediately.

Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Rare

  • Abdominal or stomach pain
  • bloating
  • bloody or black, tarry stools
  • body aches or pain
  • burning, dry, or itching eyes
  • clay-colored stools
  • congestion
  • constipation
  • cough
  • dark urine
  • decreased vision or other changes in vision
  • diarrhea
  • difficult or labored breathing
  • difficult or painful urination
  • dryness or soreness of the throat
  • excessive tearing
  • fainting
  • fast, slow, or irregular heartbeat
  • feeling of warmth
  • fever
  • heartburn
  • hoarseness
  • indigestion
  • itching
  • loss of appetite
  • pain in the eye
  • pounding in the ears
  • rash
  • redness of the face, neck, arms and occasionally, upper chest
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • severe stomach pain
  • shortness of breath
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble in swallowing
  • unpleasant breath odor
  • voice changes
  • vomiting of blood or material that looks like coffee grounds
  • wheezing
  • yellow eyes or skin
  • Decreased interest in sexual intercourse
  • dizziness or lightheadedness
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • flushing or redness of the skin
  • headache, severe and throbbing
  • hives or welts
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • mood or mental changes
  • muscle stiffness
  • muscle tension or tightness
  • sensation of spinning
  • skin rash, encrusted, scaly, and oozing
  • sleepiness or unusual drowsiness
  • unusually warm skin
  • walking in unusual manner
  • weight loss

More Common

  • Indigestion
  • passing of gas

Less Common

  • Anxiety
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • difficulty with moving
  • dizziness
  • fainting
  • fast heartbeat
  • headache
  • increased hunger
  • joint pain
  • leg cramps
  • muscle aching or cramping
  • muscle pain or stiffness
  • nausea
  • nervousness
  • nightmares
  • pain in the joints
  • problems in urination or increase in the amount of urine
  • seizures
  • shakiness
  • slurred speech
  • sweating
  • swollen joints
  • unusual tiredness or weakness
  • Acid or sour stomach
  • belching
  • excess air or gas in the stomach or intestines
  • full feeling
  • pain
  • sleeplessness
  • sneezing
  • stuffy nose
  • trouble sleeping
  • unable to sleep

Incidence Not Known

  • Agitation
  • back or leg pains
  • bleeding gums
  • blood in the urine or stools
  • chest pain
  • convulsions
  • decreased urine output
  • fluid-filled skin blisters
  • general body swelling
  • general feeling of tiredness or weakness
  • high fever
  • hostility
  • increased thirst
  • irritability
  • lethargy
  • light-colored stools
  • lower back or side pain
  • muscle twitching
  • nosebleeds
  • pinpoint red pots on the skin
  • rapid weight gain
  • sensitivity to the sun
  • skin thinness
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • swelling of the face, ankles, or hands
  • unusual bleeding or bruising
  • Increased sensitivity of the skin to sunlight
  • severe sunburn
Type Small Molecule
Accession Number DB01067  (APRD00436)
Groups Approved, Investigational
Synonyms
  • 1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea
  • Glipizida
  • Glipizide
  • Glipizidum
  • N-{4-[β-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-N'-cyclohexylurea
UNII X7WDT95N5C
CAS number 29094-61-9
Weight Average: 445.535
Monoisotopic: 445.178375067
Chemical Formula C21H27N5O4S
InChI
InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
IUPAC Name
N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-5-methylpyrazine-2-carboxamide
Protein binding

98-99%, primarily to albumin.

Toxicity

The acute oral toxicity was extremely low in all species tested (LD50 greater than 4 g/kg). Overdosage of sulfonylureas including glipizide can produce hypoglycemia.

Half life

2-5 hours

Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:

  • Algiers
  • Oran
  • Constantine
  • Annaba
  • Blida
  • Batna
  • Djelfa
  • Sétif
  • Sidi Bel Abbès
  • Biskra
  • Tébessa
  • El Oued
  • Skikda
  • Tiaret
  • Béjaïa
  • Tlemcen
  • Ouargla
  • Béchar
  • Mostaganem
  • Bordj Bou Arréridj
  • Chlef
  • Souk Ahras
  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou