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Probertan (Brand name: Avapro)

  • $0.70
  • Brand name: Avapro
  • Availability: In Stock
  • Active Ingredient Irbesartan
Probertan is used to treat hypertension and kidney problems (diabetic nephropathy) caused by diabetes.
Analogs of Probertan (Brand name: Avapro): Avalide  
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Other names of Probertan (Brand name: Avapro): a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Aprovel   Abeltan CJ   Abeltan Plus CJ   Abesart   Abisart   Acepress   Adana   Adco-Irbesartan   Agepin   Aimix HD   Aimix LD   Alvein   An Lai   An Li Bo   Apo-Irbesartan   Apo-Irbesartan/HCTZ   Aprovasc   Aprovel   Aprozar   Aprtan   Ara Plus   Ara Plus H   Arablocktans   Aradeux   Araplus   Araplus H   Araven   Arbesta   Arb-Ib   Arbit   Arbitan   Ardinel   Artibesan   Assipress   Atokken   Probertan  
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150 mg
Product name Per Pill Per Pack  
30 pills $1.25 $37.53
60 pills $0.95 $75.05 $57.04
90 pills $0.85 $112.58 $76.55
120 pills $0.80 $150.11 $96.07
180 pills $0.75 $225.16 $135.09
270 pills $0.72 $337.74 $193.64
360 pills $0.70 $450.32 $252.18
300 mg
Product name Per Pill Per Pack  
30 pills $1.61 $48.38
60 pills $1.21 $96.75 $72.80
90 pills $1.08 $145.13 $97.24
120 pills $1.01 $193.50 $121.67
180 pills $0.95 $290.25 $170.51
270 pills $0.90 $435.38 $243.81

Common use

Antihypertensive drug, antagonist of angiotensin receptors II. It specifically and irreversibly blocks receptors of angiotensin which leads to diminishing of biological effects of angiotensin II. Angiotensin II effects include vasoconstriction and stimulating influence on excretion of aldosterone and activation of sympathetic nervous system. As a consequence arterial pressure diminishes and the heart does not have to work as hard to pump blood. It does not influence concentration or triglycerides, content of cholesterol, glucose, uric acid in blood plasma and excretion of uric acid with urine.

Dosage and direction

Initial dose is 150 mg and it can be increased up to 300 mg on necessity. In some cases as low chloride diet, treatment with certain diuretics and others initial dose size should be smaller. Probertan is taken once a day preferably at the same time.

Precautions

It should be administered with kidney or liver failure, congestive heart failure, after strong vomit or diarrhea and also during simultaneous treatment with potassium saving diuretics or medications containing potassium. This drug causes serious harm to unborn baby (possibly death) if it is administered and used during the last six months of pregnancy.

Contraindications

Pregnancy, infancy, hypersensitivity to Probertan.

Possible side effect

The most common side effects include diarrhea, abdominal pain or heartburn. In case you experience allergic reaction to the medication (fever, difficult breathing, hives) contact your doctor. Probertan can cause a condition that results in the breakdown of skeletal muscle tissue and then in kidney failure. Also call your doctor if you have muscle pain, tenderness, or weakness especially if you also have vomiting, and dark colored urine, difficult urination.

Drug interaction

No important drug interactions were described for this medication. At simultaneous intake with potassium-saving diuretics level of potassium may be increased in blood plasma.

Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose

Immediate medical help is needed in case of overdose which symptoms include fast or slow heartbeat, dizziness.

Storage

Tablets should be stored at room temperature, 15-30 C (59-86 F).

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Rare

  • Chest discomfort
  • decreased urine output
  • dilated neck veins
  • extreme fatigue
  • feeling of warmth
  • fever
  • irregular breathing
  • irregular heartbeat
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • redness of the face, neck, arms, and occasionally, upper chest
  • shortness of breath
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing
  • vomiting
  • weight gain
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • bloated or full feeling
  • blurred or loss of vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in hearing
  • cracked, dry, scaly skin
  • decreased interest in sexual intercourse
  • depression
  • difficulty having a bowel movement (stool)
  • disturbed color perception
  • double vision
  • ear drainage
  • earache or pain in the ear
  • excess air or gas in the stomach or intestines
  • halos around lights
  • hives or welts
  • inability to have or keep an erection
  • large, flat, blue or purplish patches in the skin
  • loss in sexual ability, desire, drive, or performance
  • night blindness
  • overbright appearance of lights
  • pain, swelling, or redness in the joints
  • passing gas
  • sleepiness or unusual drowsiness
  • tunnel vision

More Common

  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position

Less Common

  • Bladder pain
  • bloody or cloudy urine
  • chest pain
  • difficult, burning, or painful urination
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate
  • lower back or side pain
  • Acid or sour stomach
  • belching
  • body aches or pain
  • bone pain
  • congestion
  • cough
  • diarrhea
  • dryness or soreness of the throat
  • feeling of indigestion
  • general feeling of discomfort or illness
  • heartburn
  • hoarseness
  • joint pain
  • pain in the chest below the breastbone
  • runny nose
  • shivering
  • sneezing
  • stomach discomfort or upset
  • stuffy nose
  • sweating
  • tender, swollen glands in the neck
  • trouble sleeping
  • trouble with swallowing
  • voice changes

Incidence Not Known

  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • clay-colored stools
  • dark urine
  • decreased frequency of urine
  • headache
  • increased thirst
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red spots on the skin
  • rash
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • weakness or heaviness of the legs
  • weight gain
  • yellow eyes or skin
  • Feeling of constant movement of self or surroundings
  • sensation of spinning
Type Small Molecule
Accession Number DB01029  (APRD00413)
Groups Approved, Investigational
Synonyms
  • 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
  • Irbesartan
UNII J0E2756Z7N
CAS number 138402-11-6
Weight Average: 428.5294
Monoisotopic: 428.232459548
Chemical Formula C25H28N6O
InChI
InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)
IUPAC Name
2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one
Protein binding

90% bound to serum proteins (primarily albumin and a1-acid glycoprotein) with negligible binding to cellular components of blood.

Toxicity

Hypotension and tachycardia; bradycardia might also occur from overdose, LD50=mg/kg(orally in rat)

Half life

11-15 hours

Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:

  • Algiers
  • Oran
  • Constantine
  • Annaba
  • Blida
  • Batna
  • Djelfa
  • Sétif
  • Sidi Bel Abbès
  • Biskra
  • Tébessa
  • El Oued
  • Skikda
  • Tiaret
  • Béjaïa
  • Tlemcen
  • Ouargla
  • Béchar
  • Mostaganem
  • Bordj Bou Arréridj
  • Chlef
  • Souk Ahras
  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou