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Pemidal (Brand name: Amaryl)
- $0.48
Azulix Aylide Avaron Avandaryl Avandaglim Avaglim Asoride Aramil Apo-glimepiride Apo-glimep Apo-glim Anpiride Amyx Amyline Amarylle Amarwin Amarine Amarel Amagen Amadin Amadiab Adiuvan Adinsulin Adglim Abepride Accord-Glimepride Acotril Actaryl Adglim Adglim-M Adinsulin-S Adiuvan Adride Adride-M Aforglim Amadiab Amadm Amagen Amagreen Amara Amarax Amarel Amaride Amarine Amaryl Combi Amaryl m Amaryl M Forte Amaryl M SR Amaryl OD Amaryl XM Amarylle Amaryl-P Amoli Amyline Amyx An Duo Mei Anpiride Apo-Glimepirid Apo-glimepiride Arya Asenza Plus Asoride Asoride-M Aspen Glimepiride Austell-Glimepiride Avaglim Avandaryl Avaron Avglim Azulix Azulix-MF Pemidal
| Product name | Per Pill | Savings | Per Pack | |
|---|---|---|---|---|
| 30 pills | $1.89 | $56.64 | ||
| 60 pills | $1.51 | $22.86 | $113.29 $90.43 | |
| 90 pills | $1.38 | $45.73 | $169.93 $124.20 | |
| 120 pills | $1.32 | $68.59 | $226.57 $157.98 | |
| 180 pills | $1.25 | $114.32 | $339.86 $225.54 | |
| 270 pills | $1.21 | $182.90 | $509.79 $326.89 | |
| 360 pills | $1.19 | $251.50 | $679.72 $428.22 |
| Product name | Per Pill | Savings | Per Pack | |
|---|---|---|---|---|
| 30 pills | $1.42 | $42.67 | ||
| 60 pills | $1.12 | $18.15 | $85.34 $67.19 | |
| 90 pills | $1.02 | $36.31 | $128.01 $91.70 | |
| 120 pills | $0.97 | $54.46 | $170.68 $116.22 | |
| 180 pills | $0.92 | $90.76 | $256.01 $165.26 | |
| 270 pills | $0.88 | $145.23 | $384.02 $238.79 | |
| 360 pills | $0.87 | $199.69 | $512.03 $312.34 |
| Product name | Per Pill | Savings | Per Pack | |
|---|---|---|---|---|
| 60 pills | $0.82 | $49.39 | ||
| 90 pills | $0.68 | $12.45 | $74.08 $61.63 | |
| 120 pills | $0.62 | $24.89 | $98.77 $73.88 | |
| 180 pills | $0.55 | $49.79 | $148.16 $98.37 | |
| 270 pills | $0.50 | $87.13 | $222.24 $135.11 | |
| 360 pills | $0.48 | $124.45 | $296.32 $171.86 |
| Product name | Per Pill | Savings | Per Pack | |
|---|---|---|---|---|
| 30 pills | $1.64 | $49.20 | ||
| 60 pills | $1.30 | $20.39 | $98.40 $78.01 | |
| 90 pills | $1.19 | $40.79 | $147.60 $106.81 | |
| 120 pills | $1.13 | $61.19 | $196.80 $135.61 | |
| 180 pills | $1.07 | $101.97 | $295.20 $193.23 | |
| 270 pills | $1.04 | $163.16 | $442.80 $279.64 | |
| 360 pills | $1.02 | $224.35 | $590.40 $366.05 |
Product Description
Common use
Pemidal is an oral blood sugar-lowering drug which belongs to the class of sulfonylureas. Active substance is Glimepiride. It is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. The mechanism of its action is to stimulate the secretion and release of insulin from beta cells of the pancreas (pancreatic effect). Pemidal is used to treat non-insulin depending diabetes (type 2) as monotherapy or in combination with insulin (or metformin).
Dosage and direction
The best dose is determined by a physician on a basis of regular measurements of blood sugar content.
Precautions
Be careful your sugar does not fall too low due to stress, skipping a meal, exercising too long, or drinking alcohol. Know signs of hypoglycemia and keep a source of sugar at hand. If your sugar level is too high you may feel very thirsty or hungry. You may also urinate more than usual. Take this medication exactly as prescribed as it is a part of a complicated program consisting of diet, medication, and exercise routines. Tell your doctor if you are pregnant or plan to become pregnant, have adrenal or pituitary gland problems before taking this medication.
Contraindication
Pemidal is contraindicated in patients with history of diabetic ketoacidosis, diabetic coma and prekoma, insulin-dependent diabetes (type 1), severe renal dysfunction, severe hepatic impairment, individual hypersensitivity to Pemidal, other members of sulfonylurea class and sulfonamides.
Possible side effect
If you have any signs of allergic reaction to this medication such as hives, swelling of face and throat, rash or other major symptoms (severe skin rash, itching, redness, pale skin, easy bruising or bleeding, numbness, dark urine, clay-colored stools, abdominal pain, fever, nausea)seek for immediate medical help.
Drug interaction
Diuretics like hydrochlorothiazide (Hydrodiuril, Ezide, Hydro-Par, Microzide, furosemide (Lasix)), corticosteroids such as prednisone and methylprednisolone (Medrol), phenytoin (Dilantin), niacin, and sympathomimetics such as pseudoephedrine (Sudafed) are able to increase blood sugar and diminish effect of Pemidal. Propranolol (Inderal) and atenolol (Tenormin) belong to beta-blockers and also are able to affect blood levels and decrease activity of Pemidal.
Missed dose
Take the missed dose as soon as you remember about it. If it is almost time of your next dose just skip it and return to your regular schedule.
Overdose
Immediate medical attention is needed in case you took too much medicine. Possible side effects include: extreme weakness, confusion, blurred vision, stomach pain, trouble speaking, tremors, sweating, seizure, and coma.
Storage
Store at room temperature in a tight container and keep away from sunlight, moisture, kids and pets.
Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:
Less Common
- Lack or loss of strength
Incidence Not Known
- Abdominal or stomach pain
- agitation
- back, leg, or stomach pains
- bleeding gums
- blistering, peeling, or loosening of the skin
- bloating of abdomen
- blood in the urine or stools
- bloody, black, or tarry stools
- chest pain
- chills
- coma
- confusion
- cough or hoarseness
- dark urine
- decreased urine output
- depression
- diarrhea
- difficulty with breathing
- fever with or without chills
- fluid-filled skin blisters
- general body swelling
- general tiredness and weakness
- headache
- high fever
- hostility
- irritability
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- lethargy
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle twitching
- nausea and vomiting
- nosebleeds
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- red, irritated eyes
- red skin lesions, often with a purple center
- seizures
- sensitivity to the sun
- skin thinness
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stupor
- swelling of face, ankles, or hands
- swollen or painful glands
- unusual bleeding or bruising
- upper right abdominal or stomach pain
- yellow eyes or skin
- Redness or other discoloration of the skin
- severe sunburn
| Type | Small Molecule |
| Accession Number | DB00222 (APRD00381) |
| Groups | Approved |
| Synonyms |
|
| UNII | 6KY687524K |
| CAS number | 93479-97-1 |
| Weight | Average: 490.62 Monoisotopic: 490.224991385 |
| Chemical Formula | C24H34N4O5S |
| InChI | InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19- |
| IUPAC Name | 3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]-C-hydroxycarbonimidoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboximidic acid |
| Protein binding | Over 99.5% bound to plasma protein. |
| Toxicity | Severe hypoglycemic reactions with coma, seizure, or other neurological impairment. |
| Half life | Approximately 5 hours following single dose. |
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