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Pioglitazon (Brand name: Actoplus Met)
Apo-Pioglitazone Adpas Actose Actos Met Adglim-M Aglikem Alexodiab Amaryl m Amaryl M Forte Amaryl M SR Amophage Andibet Anglucid Anhe Asegur Asoformin Asoformin-P Asoride-M Avandamet Accord Metformin Actomeg ActoPlus met XR Actos M Actosmet Adecco Adimet Adride-M Agimfor Aglumet Aglurab Amaryl Combi Amaryl XM Ammiformin Andm Anformin Ankomin Ansures Ansures ER Antigluco Anxofin Anxoken Apo-Metformin Aromet Arrow Metformine HCL Asformin Austell-Metformin Avamina Azulix-MF Accord Pioglitazone Actose Actozone Adpas Amaryl-P Apo-Pioglitazone Acpio Actazone Actos OD Anxotos Pioglitazon
|Product name||Per Pill||Savings||Per Pack|
|60 pills||$1.18||$15.52||$86.21 $70.69|
|90 pills||$1.09||$31.03||$129.31 $98.28|
|120 pills||$1.05||$46.56||$172.42 $125.86|
|180 pills||$1.01||$77.60||$258.62 $181.03|
|270 pills||$0.98||$124.15||$387.94 $263.79|
|360 pills||$0.96||$170.71||$517.25 $346.54|
Pioglitazon is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.
How to use
Use Pioglitazon as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with Pioglitazon . Talk to your pharmacist if you have questions about this information.
Take Pioglitazon by mouth with meals.
Take Pioglitazon on a regular schedule to get the most benefit from it. Taking Pioglitazon at the same times each day will help you remember to take it.
Continue to take Pioglitazon even if you feel well. Do not miss any doses.
Drug Class and Mechanism
Pioglitazon is a biguanide and thiazolidinedione antidiabetic combination. It works by decreasing the amount of sugar the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.
If you miss a dose of Pioglitazon , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Store this medicine at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted.
Do NOT use Pioglitazon if:
you are allergic to any ingredient in Pioglitazon
you have type 1 diabetes
you have moderate to severe heart failure
you have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated
you have had a stroke or a recent heart attack, or you are in shock
you are 80 years old or more and have not had a kidney function test
you will be having surgery or certain lab procedures
you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Pioglitazon . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a history of heart problems (eg, heart failure), abnormal liver function tests, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, eye or vision problems (eg, macular degeneration), bladder cancer, or lactic acidosis
if you have fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia, or if you are dehydrated
if you have an infection, fever, recent injury, or moderate to severe burns
if you have a history of bone fracture, weak bones (eg, osteoporosis), or low calcium intake
if you drink alcohol or have a history of alcohol abuse
if you will be having surgery or certain lab procedures
if you take a beta-blocker (eg, propranolol)
Some MEDICINES MAY INTERACT with Pioglitazon . Tell your health care provider if you are taking any other medicines, especially any of the following:
Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of Pioglitazon 's side effects
Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (eg, glipizide), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased
Gemfibrozil because it may increase the risk of Pioglitazon 's side effects
Rifampin because it may decrease Pioglitazon 's effectiveness, resulting in high blood sugar
Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may be increased by Pioglitazon
Possible Side Effects
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Cold-like symptoms; diarrhea; headache; indigestion; mild weight gain; nausea; stomach upset.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; bone pain; chest pain or discomfort; dark urine; difficult or painful urination; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; pale stools; persistent loss of appetite; severe or persistent headache, nausea, or vomiting; shortness of breath; slow or irregular heartbeat; sudden unexplained weight gain; swelling of the hands, ankles, or feet; unusual stomach pain or discomfort; unusual drowsiness; unusual tiredness or weakness; yellowing of the eyes or skin.
If you have any questions about Pioglitazon , please talk with your doctor, pharmacist, or other health care provider.
Pioglitazon is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
If using Pioglitazon for an extended period of time, obtain refills before your supply runs out.
Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:
- Chest pain
- decreased urine output
- dilated neck veins
- extreme fatigue
- irregular breathing
- irregular heartbeat
- problems with teeth
- swelling of the face, fingers, feet, or lower legs
- tightness in the chest
- trouble breathing
- weight gain
- Blurred vision or other changes in vision
- dry mouth
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- loss of consciousness
- muscle pain or soreness
- problems with your teeth
- runny or stuffy nose
- sore throat
- unexplained weight loss
- Pain or swelling in the arms or legs without an injury
- pale skin
- trouble with breathing when active
- unusual bleeding or bruising
- unusual tiredness or weakness
Incidence Not Known
- Dark urine
- loss of appetite
- nausea or vomiting
- stomach pain
- unexplained, rapid weight gain
- yellow eyes or skin
|Accession Number||DB01132 (APRD00653)|
Pioglitazone is extensively protein bound (> 99%) in human serum, principally to serum albumin. Pioglitazone also binds to other serum proteins, but with lower affinity [Label].
The mean serum half-life of pioglitazone and its metabolites (M-III and M-IV) range from 3 to 7 hours and 16 to 24 hours, respectively [Label].
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