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Pragmarel (Brand name: Trazodone)

  • $0.71
  • Brand name: Trazodone
  • Availability: In Stock
  • Active Ingredient Trazodone
Pragmarel is a tetracyclic antidepressant and may also be used to relieve an anxiety disorder.
Analogs of Pragmarel (Brand name: Trazodone): Desyrel  
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Apo-Trazodone   Aspen Trazodone   Pragmarel  
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100 mg
Product name Per Pill Per Pack  
30 pills $1.10 $32.92
60 pills $0.89 $65.84 $53.27
90 pills $0.82 $98.76 $73.62
120 pills $0.78 $131.68 $93.96
180 pills $0.75 $197.51 $134.66
270 pills $0.72 $296.27 $195.72
360 pills $0.71 $395.03 $256.75

Drug Uses

Pragmarel is used for treating depression. It may also be used for relief of an anxiety disorder (e.g., insomnia, tension), chronic pain. It may also be used for other conditions as determined by your doctor.

How to use

Use Pragmarel as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Pragmarel comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Pragmarel refilled.
Take Pragmarel shortly after a meal or light snack.
It may take 1 to 4 weeks for Pragmarel to work. Do not stop taking Pragmarel without checking with your doctor.

Drug Class and Mechanism

Pragmarel is a tetracyclic antidepressant. It is thought to increase the activity of one of the brain chemicals (serotonin), which helps elevate mood.

Missed Dose

If you miss a dose of Pragmarel and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Pragmarel between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pragmarel out of the reach of children and away from pets.

Warnings/Precautions

Do not use Pragmarel if:

you are allergic to any ingredient in Pragmarel or nefazodone;
you are taking sodium oxybate (GHB).
Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Pragmarel . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have heart disease including irregular heartbeat or have had a heart attack
if you have a history of depression or suicidal tendencies
if you are scheduled to have surgery
if you consume alcoholic beverages

Some MEDICINES MAY INTERACT with Pragmarel . Tell your health care provider if you are taking any other medicines, especially any of the following:
Carbamazepine, ethanol, ginkgo biloba, HIV protease inhibitors (eg, ritonavir), phenothiazines (eg, thioridazine), or serotonin reuptake inhibitors (eg, fluoxetine) because side effects, such as increased drowsiness or blurred vision, may occur
Buspirone, carbamazepine, digoxin, hydantoins (eg, phenytoin), itraconazole, ketoconazole, nefazodone, serotonin reuptake inhibitors (eg, fluoxetine), or sodium oxybate (GHB) because the risk of their side effects may be increased by Pragmarel
 Anticoagulants (eg, warfarin) because they may decrease Pragmarel 's effectiveness. Your doctor may want to adjust your dose while taking Pragmarel

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

blurred vision; constipation; decreased appetite; dizziness; drowsiness; dry mouth; general body discomfort; headache; incoordination; light-headedness; muscle aches/pains; nausea; nervousness; sleeplessness; stomach pain; stuffy nose; swelling of the skin; tiredness; tremors.
Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in urine; chest pain; fainting; hallucinations; irregular heartbeat; light-headedness when rising from a lying or seated position; prolonged, inappropriate, or painful erections; seizures; shortness of breath; stroke; vomiting.

More Information

If you have any questions about Pragmarel, please talk with your doctor, pharmacist, or other health care provider.
Pragmarel is to be used only by the patient for whom it is prescribed. Do not share it with other people.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Rare

  • Skin rash
  • unusual excitement

More Common

  • Blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • lightheadedness
  • sweating
  • unusual tiredness or weakness
  • Dry mouth (usually mild)
  • muscle or bone pain
  • trouble sleeping
  • trouble with remembering
  • unpleasant taste

Less Common

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion about identity, place, and time
  • decreased concentration
  • fainting
  • general feeling of discomfort or illness
  • headache
  • lack of coordination
  • muscle tremors
  • nervousness
  • pounding in the ears
  • shortness of breath
  • slow or fast heartbeat
  • swelling
  • Constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • diarrhea
  • hearing loss
  • muscle aches or pains
  • weight loss
Type Small Molecule
Accession Number DB00656  (APRD00533)
Groups Approved, Investigational
Synonyms
  • 2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
  • Trazodona
  • Trazodone
  • Trazodonum
UNII YBK48BXK30
CAS number 19794-93-5
Weight Average: 371.864
Monoisotopic: 371.151288058
Chemical Formula C19H22ClN5O
InChI
InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
IUPAC Name
2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one
Protein binding

89-95% bound to plasma proteins in vitro

Toxicity

LD50=96mg/kg (i.v. in mice)

Half life

Undergoes biphasic elimination with an initial phase t1/2 α of 3-6 hours and a terminal phase t1/2 β of 5-9 hours.

Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:

  • Algiers
  • Oran
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  • Sétif
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  • Mostaganem
  • Bordj Bou Arréridj
  • Chlef
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  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou