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Paxtibi (Brand name: Pamelor)
|Product name||Per Pill||Savings||Per Pack|
|90 pills||$0.60||$4.41||$58.05 $53.64|
|120 pills||$0.57||$8.82||$77.40 $68.58|
|180 pills||$0.55||$17.64||$116.10 $98.46|
|270 pills||$0.53||$30.89||$174.15 $143.26|
|360 pills||$0.52||$44.10||$232.20 $188.10|
Paxtibi (Nortriptyline) is in a group of drugs called tricyclic antidepressants. Nortriptyline affects chemicals in the brain that may become unbalanced.
Nortriptyline is used to treat symptoms of depression.
Nortriptyline may also be used for other purposes not listed in this medication guide.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication. Follow the directions on your prescription label.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking nortriptyline. You may need to stop using the medicine for a short time.
Do not stop using nortriptyline without first talking to your doctor. You may need to use less and less before you stop the medication completely. Stopping this medication suddenly could cause you to have unpleasant side effects. It may take a few weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve during treatment with nortriptyline.
Take the medicine as prescribed by your doctor.
If you miss a dose of Paxtibi , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you take 1 dose daily at bedtime, do not take the missed dose the next morning.
Store Paxtibi between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Paxtibi out of the reach of children and away from pets.
Active ingredient: Nortriptyline
Do not use this medication if you are allergic to nortriptyline, or if you have recently had a heart attack. Do not use nortriptyline if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take nortriptyline before the MAO inhibitor has cleared from your body.
Before taking Paxtibi, tell your doctor if you are allergic to any drugs, or if you have:
a history of heart attack, stroke, or seizures;
bipolar disorder (manic-depression);
schizophrenia or other mental illness;
diabetes (nortriptyline may raise or lower blood sugar);
problems with urination.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take nortriptyline.
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether nortriptyline passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Older adults may be more likely to have side effects from this medication.
Do not give this medication to anyone under 18 years old without the advice of a doctor.
Important safety information:
Avoid drinking alcohol. It can cause dangerous side effects when taken together with nortriptyline.
Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, medicine for seizures, or other antidepressants). They can add to sleepiness caused by nortriptyline.
Grapefruit and grapefruit juice may interact with nortriptyline. Discuss the use of grapefruit products with your doctor before increasing or decreasing the amount of grapefruit products in your diet.
Nortriptyline can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Nortriptyline can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects:
fast, pounding, or uneven heart rate;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision, speech, or balance;
confusion, hallucinations, or seizure (convulsions);
easy bruising or bleeding, unusual weakness;
restless muscle movements in your eyes, tongue, jaw, or neck;
extreme thirst with headache, nausea, vomiting, and weakness;
feeling light-headed or fainting; or
urinating less than usual or not at all.
Less serious side effects may include:
nausea, vomiting, stomach pain, loss of appetite;
constipation or diarrhea;
dry mouth, unpleasant taste;
weakness, lack of coordination;
numbness or tingly feeling;
blurred vision, headache, ringing in your ears;
mild skin rash;
breast swelling (in men or women); or
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:
Incidence Not Known
- Abdominal or stomach pain
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain or discomfort
- clay-colored stools
- cold sweats
- confusion about identity, place, and time false beliefs that cannot be changed by facts
- continuing ringing or buzzing or other unexplained noise in the ears
- decreased urination
- difficulty in passing urine (dribbling)
- difficulty with speaking
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- double vision
- fast, pounding, or irregular heartbeat or pulse
- feeling of warmth
- feeling, seeing, or hearing things that are not there
- feeling that others are watching you or controlling your behavior
- feeling that others can hear your thoughts
- general feeling of tiredness or weakness
- inability to move the arms, legs, or facial muscles
- inability to speak
- loss of balance control
- lower back or side pain
- mood or mental changes
- muscle spasm or jerking of all extremities
- muscle trembling, jerking, or stiffness
- pain or discomfort in the arms, jaw, back, or neck
- painful or difficult urination
- pinpoint red or purple spots on the skin
- redness of the face, neck, arms, and occasionally, upper chest
- slurred speech
- sores, ulcers, or white spots on the lips or in the mouth
- stiffness of the limbs
- swelling of the face, ankles, legs, or hands
- talking, feeling, and acting with excitement
- trouble sleeping
- twisting movements of the body uncontrolled movements, especially of the face, neck, and back
- weakness in the arms, hands, legs, or feet
- Bigger, dilated, or enlarged pupils (black part of the eye)
- black tongue
- decreased interest in sexual ability or desire
- difficulty having a bowel movement (stool)
- enlargement of the breast
- hair loss or thinning of the hair
- hives or welts
- increase in sexual ability or desire
- increased sensitivity of the eyes or skin to light
- pain or discomfort in the chest, upper stomach, or throat
- peculiar taste
- severe sunburn
- small red or purple spots on the skin
- swelling of the testicles
- swelling or inflammation of the mouth
- swollen, painful, or tender lymph glands on side of face or neck
- vision changes
- waking to urinate at night
|Accession Number||DB00540 (APRD00602)|
Plasma protein binding is approximately 93% .
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia. Oral LD50 in rat is 405 mg/kg [MSDS].
The elimination half-life (t 1⁄2β) after oral nortriptyline administration is approximately 26 hours (25.5 ± 7.9 hours; range 16-38 hours) .
Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:
- Sidi Bel Abbès
- El Oued
- Bordj Bou Arréridj
- Souk Ahras
- El Eulma
- Aïn Béïda
- Tizi Ouzou