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Praminex (Brand name: Anafranil)

  • $0.32
  • Brand name: Anafranil
  • Availability: In Stock
  • Active Ingredient Clomipramine
Praminex works on the central nervous system and treats obsessive compulsive disorder, panic attacks, depression, and ongoing pain.
Other names of Praminex (Brand name: Anafranil): a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Anafranil SR   Anafronil   Anafronil SR   Anapramine   Anapramine SR   Ausentron   Anafranil retard   Anafril   Praminex  
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75 mg
Product name Per Pill Per Pack  
30 pills $2.60 $77.90
60 pills $2.10 $155.81 $126.01
90 pills $1.93 $233.71 $174.11
120 pills $1.85 $311.62 $222.23
180 pills $1.77 $467.42 $318.44
270 pills $1.71 $701.14 $462.75
50 mg
Product name Per Pill Per Pack  
30 pills $1.87 $56.18
60 pills $1.48 $112.36 $89.07
90 pills $1.36 $168.53 $121.96
120 pills $1.29 $224.71 $154.85
180 pills $1.23 $337.07 $220.63
270 pills $1.18 $505.60 $319.30
360 pills $1.16 $674.14 $417.96
10 mg
Product name Per Pill Per Pack  
60 pills $0.52 $31.19
90 pills $0.44 $46.78 $39.48
120 pills $0.40 $62.38 $47.78
180 pills $0.36 $93.56 $64.37
270 pills $0.33 $140.35 $89.26
360 pills $0.32 $187.13 $114.16
25 mg
Product name Per Pill Per Pack  
30 pills $1.13 $33.80
60 pills $0.88 $67.59 $52.84
90 pills $0.80 $101.39 $71.89
120 pills $0.76 $135.18 $90.94
180 pills $0.72 $202.77 $129.04
270 pills $0.69 $304.16 $186.19
360 pills $0.68 $405.54 $243.32

Product Description

Common use

Praminex is a drug used to treat obsessive compulsive disorder (OCD). This is a nervous condition where a person has recurring thoughts or ideas, or does repetitive things because they are anxious.
Clomipramine works on the central nervous system (CNS) and helps to relieve the symptoms of OCD. This medication belongs to a class of so called tricyclic antidepressants. It helps to restore the balance of certain natural substances (serotonin, among others) in the brain.
This medication is also used to treat panic attacks, depression, and ongoing pain.

Dosage and direction

Take the drug only as prescribed because dosage and schedule may vary on your condition and other factors.
It is advised to follow the doctor's instructions carefully and not to take more or less medication than prescribed.
It is advised not to eat grapefruit or drink grapefruit juice ( it influences the level of cyclosporin in your blood ). Also limit alcoholic beverages.
Do not suddenly stop taking this medication as your condition may become worse.
It may take 2 to 3 weeks or longer before you notice the effects of this medication. Inform your doctor about your condition.


Before you start taking Clomipramine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Inform your doctor or pharmacist if you have certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG).
You may feel dizzy or drowsy or have temporary blurred vision. Avoid driving, using machinery, or doing any activity that requires alertness.
Aged people may be more sensitive to the side effects of the drug.
During pregnancy this medication should be used only when strongly needed. Consult your doctor about the risks.
This medicine passes into breast milk so it may have undesirable effects on a nursing infant. It is better to stop breast-feeding while using this drug.

Possible side effect

The most common side effects are dizziness, dry mouth, drowsiness, constipation, stomach upset, nausea, vomiting, sweating etc. Anxiety symptoms may temporarily worsen when you first start using Clomipramine.
A serious allergic reaction to this drug is very rare, but seek immediate medical help if it occurs.
Many people using this medicine do not have serious side effects.
In case you notice any side effects not listed above, contact your doctor or pharmacist.

Drug interaction

Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before using this medication.
Avoid taking Clomipramine with:
* MAO inhibitors: Furazolidone, Isocarboxazid, Linezolid, Moclobemide Tranylcypromine, etc.
* anti-arrhythmic medication: Propafenone, Quinidine, etc.
* Selective Serotonin Reuptake Inhibitors (SSRIs): Citalopram, Dapoxetine, Fluoxetine, Fluvoxamine, Paroxetine, etc.
* Antipsychotics (also called neuroleptics): Fluphenazine, etc.
* H2-receptor antagonists: Cimetidine, Ranitidine, Famotidine, Nizatidine, etc.
Nicotine decreases blood levels of this medication. Inform your doctor if you smoke or if you have recently stopped smoking.
Try not to eat grapefruit or drink grapefruit juice while being treated with this medication.
Consult your doctor or pharmacist for more details.

Missed dose

If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take the dose twice.


If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.


Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from children and pets.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Type Small Molecule
Accession Number DB01242  (APRD00253, DB07600)
Groups Approved, Investigational, Vet approved
  • 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
  • 3-(3-chloro-5H-dibenzo[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine
  • 3-Chloroimipramine
  • Chlorimipramine
  • Clomipramina
  • Clomipraminum
  • Monochlorimipramine
CAS number 303-49-1
Weight Average: 314.852
Monoisotopic: 314.154976453
Chemical Formula C19H23ClN2
Protein binding

Clomipramine is approximately 97-98% bound to plasma proteins, principally to albumin and possibly to α1-acid glycoprotein. Desmethylclomipramine is 97-99% bound to plasma proteins.


Signs and symptoms vary in severity depending upon factors such as the amount of drug absorbed, the age of the patient, and the time elapsed since drug ingestion. Critical manifestations of overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity. In U.S. clinical trials, 2 deaths occurred in 12 reported cases of acute overdosage with Anafranil either alone or in combination with other drugs. One death involved a patient suspected of ingesting a dose of 7000 mg. The second death involved a patient suspected of ingesting a dose of 5750 mg. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.

Half life

Following oral administration of a single 150 mg dose of clomipramine, the average elimination half-life of clomipramine was 32 hours (range: 19-37 hours) and of desmethylclomipramine was 69 hours (range: 54-77 hours). Elimination half-life may vary substantially with different doses due to saturable kinetics (i.e. metabolism).

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