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Pharex Simvastatin (Brand name: Zocor)

  • $0.67
  • Brand name: Zocor
  • Availability: In Stock
  • Active Ingredient simvastatin
Pharex Simvastatin is used for lowering high cholesterol and triglycerides in certain patients.
Analogs of Pharex Simvastatin (Brand name: Zocor): Vytorin  
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Other names of Pharex Simvastatin (Brand name: Zocor): a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Actalipid   Adacai   Adco-Simvastatin   Afordel   Alcosin   Alipas Duo   Alistim   Alkor   Alkor Plus   Alpheus   Altovast   Amristatin   Amvestin   Antichol   Apo Simvastatin   Apo-Simva   Apo-Simvastatin   Arrow Simva   Arrow Simvastatin   Arstatin   Arudel   Aspen Simvastatin   Astax   Astin   Atcol   Aterexa   Austell-Simvastatin   Avastin   Avastinee   Pharex Simvastatin  
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5 mg
Product name Per Pill Per Pack  
30 pills $1.11 $33.36
60 pills $0.87 $66.71 $52.16
90 pills $0.79 $100.07 $70.96
120 pills $0.75 $133.43 $89.76
180 pills $0.71 $200.14 $127.37
270 pills $0.68 $300.21 $183.76
360 pills $0.67 $400.28 $240.16
20 mg
Product name Per Pill Per Pack  
30 pills $1.29 $38.76
60 pills $1.08 $77.52 $64.84
90 pills $1.01 $116.28 $90.91
120 pills $0.97 $155.04 $116.99
180 pills $0.94 $232.56 $169.13
270 pills $0.92 $348.84 $247.35
360 pills $0.90 $465.12 $325.58
10 mg
Product name Per Pill Per Pack  
30 pills $1.14 $34.20
60 pills $0.89 $68.40 $53.11
90 pills $0.80 $102.60 $72.01
120 pills $0.76 $136.80 $90.91
180 pills $0.72 $205.20 $128.72
270 pills $0.69 $307.80 $185.44
360 pills $0.67 $410.40 $242.14
40 mg
Product name Per Pill Per Pack  
30 pills $2.66 $79.65
60 pills $1.92 $159.31 $115.40
90 pills $1.68 $238.96 $151.14
120 pills $1.56 $318.61 $186.89
180 pills $1.44 $477.92 $258.37
270 pills $1.35 $716.88 $365.61

INDICATIONS

Pharex Simvastatin is used for lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL, "good") cholesterol levels. It is used along with an appropriate diet. It is used in certain patients to reduce the risk of heart attack, stroke, and death due to coronary heart disease. It is also used to reduce the need for medical procedures to open blocked blood vessels. It is also used in certain patients to reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina. Pharex Simvastatin is an HMG-CoA reductase inhibitor, also known as a "statin." It works by reducing the production of certain fatty substances in the body, including cholesterol.

INSTRUCTIONS 

Use Pharex Simvastatin as directed by your doctor.

  • Take Pharex Simvastatin by mouth with or without food.
  • Eating grapefruit or drinking grapefruit juice may increase the amount of Pharex Simvastatin in your blood, which may increase your risk for serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice (eg, more than one quart daily). Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking Pharex Simvastatin.
  • Continue to take Pharex Simvastatin even if you feel well. Do not miss any doses.
  • If you miss a dose of Pharex Simvastatin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pharex Simvastatin.

STORAGE

Store Pharex Simvastatin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pharex Simvastatin out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Simvastatin.

SAFETY INFORMATION

Do NOT use Pharex Simvastatin if:

  • you are allergic to any ingredient in Pharex Simvastatin
  • you have liver problems or unexplained abnormal liver function tests
  • you are pregnant or breast-feeding
  • you are taking a macrolide antibiotic (eg, clarithromycin, erythromycin), an HIV protease inhibitor (eg, ritonavir), itraconazole, ketoconazole, mibefradil, nefazodone, or telithromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Pharex Simvastatin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have low blood pressure, kidney problems, diabetes, a serious infection, or a history of seizures
  • if you have metabolism, hormonal, or electrolyte problems
  • if you drink alcohol or have a history of liver problems or alcohol abuse
  • if you have recently had major surgery or a serious injury.

Some medicines may interact with Pharex Simvastatin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Amiodarone, certain azole antifungals (eg, itraconazole, ketoconazole), danazol, diltiazem, fibrates (eg, gemfibrozil, clofibrate), fluconazole, HIV protease inhibitors (eg, ritonavir), imatinib, immunosuppressants (eg, cyclosporine), macrolide antibiotics (eg, clarithromycin, erythromycin), mibefradil, nefazodone, niacin, non-nucleoside reverse transcriptase inhibitors (eg, delavirdine), risperidone, streptogramins (eg, dalfopristin), telithromycin, vasopressin receptor antagonists (eg, conivaptan), verapamil, or voriconazole because they may increase the risk of muscle or kidney problems
  • Bosentan, carbamazepine, rifampin, or St. John's wort because they may decrease Pharex Simvastatin's effectiveness
  • Anticoagulants (eg, warfarin), digoxin, macrolide immunosuppressants (eg, tacrolimus), or spironolactone because the risk of their side effects may be increased by Pharex Simvastatin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pharex Simvastatin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Drinking alcohol daily or in large amounts may increase the risk of liver problems with Pharex Simvastatin. Check with your doctor before drinking alcohol while you are taking Pharex Simvastatin.
  • Follow the diet and exercise program given to you by your health care provider.
  • Tell your doctor or dentist that you take Pharex Simvastatin before you receive any medical or dental care, emergency care, or surgery.
  • Women who may become pregnant should use effective birth control while taking Pharex Simvastatin. Check with your doctor if you have questions about using birth control.
  • Do not take more than the recommended dose without checking with your doctor.
  • Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort.
  • Rarely, changes to the skin, hair, and nails (eg, discoloration, dryness, hair loss) may occur. Check with your doctor if these effects become bothersome or cause you concern.
  • Lab tests, including blood cholesterol levels, liver function tests, and creatine phosphokinase (CPK) blood levels, may be performed while you use Pharex Simvastatin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Pharex Simvastatin should be used with extreme caution in children younger 10 years and in those who have not reached puberty; safety and effectiveness in these children have not been confirmed.
  • Pregnancy and breast-feeding: Do not use Pharex Simvastatin if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Pharex Simvastatin is found in breast milk. Do not breastfeed while taking Pharex Simvastatin.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; muscle pain, tenderness, or weakness (with or without fever and fatigue); pale stools; red, swollen, blistered, or peeling skin; severe or persistent stomach pain; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

More Common

  • Dizziness
  • fainting
  • fast or irregular heartbeat

Less Common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • chills
  • cough
  • dark-colored urine
  • difficult, burning, or painful urination
  • difficulty with breathing
  • difficulty with moving
  • dry mouth
  • ear congestion
  • fever
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • joint pain
  • loss of consciousness
  • lower back or side pain
  • muscle cramps, spasms, or stiffness
  • muscular pain, tenderness, wasting, or weakness
  • nasal congestion
  • nausea
  • runny nose
  • sneezing
  • sore throat
  • stomachache
  • sweating
  • swelling
  • swollen joints
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting
  • Acid or sour stomach
  • belching
  • burning feeling in the chest or stomach
  • dizziness or lightheadedness
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • full feeling
  • heartburn
  • lack or loss of strength
  • pain or tenderness around the eyes and cheekbones
  • passing gas
  • sensation of spinning
  • skin rash, encrusted, scaly, and oozing
  • stomach discomfort, upset, or pain
  • tenderness in the stomach area
  • trouble sleeping

Incidence Not Known

  • Blistering, peeling, or loosening of the skin
  • bloating
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • constipation
  • diarrhea
  • difficulty with swallowing
  • general tiredness and weakness
  • indigestion
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • skin rash, hives, or itching
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • weakness in the arms, hands, legs, or feet
  • yellow eyes or skin
  • Being forgetful
  • depression
  • discoloration of the skin
  • hair loss or thinning of the hair
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
Type Small Molecule
Accession Number DB00641  (APRD00104)
Groups Approved
Synonyms
  • 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
  • Simvastatin
  • Simvastatina
  • Simvastatine
  • Simvastatinum
  • Synvinolin
UNII AGG2FN16EV
CAS number 79902-63-9
Weight Average: 418.5662
Monoisotopic: 418.271924326
Chemical Formula C25H38O5
InChI
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
IUPAC Name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Protein binding

Both simvastatin and its β-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.

Toxicity

The most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).

Half life

3 hours

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  • Algiers
  • Oran
  • Constantine
  • Annaba
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  • Djelfa
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  • Bordj Bou Arréridj
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  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou