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Prinizide (Brand name: Zestoretic)

  • $0.92
  • Brand name: Zestoretic
  • Availability: In Stock
  • Active Ingredient lisinopril
Prinizide is used for lowering high blood pressure.
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17.5 mg
Product name Per Pill Per Pack  
30 pills $1.48 $44.33
60 pills $1.17 $88.65 $70.28
90 pills $1.07 $132.98 $96.23
120 pills $1.02 $177.30 $122.17
180 pills $0.97 $265.95 $174.08
270 pills $0.93 $398.93 $251.94
360 pills $0.92 $531.90 $329.80


Prinizide is used for lowering high blood pressure. Prinizide is an angiotensin-converting enzyme (ACE) inhibitor and thiazide diuretic combination. It works by removing excess fluid from the body and causing blood vessels to relax or widen.


Use Prinizide as directed by your doctor.

  • Take Prinizide by mouth with or without food.
  • If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Prinizide.
  • Take Prinizide on a regular schedule to get the most benefit from it.
  • Taking Prinizide at the same time each day will help you remember to take it.
  • Continue to use Prinizide even if you feel well. Do not miss any dose.
  • If you miss a dose of Prinizide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prinizide.


Store Prinizide at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prinizide out of the reach of children and away from pets.


Active Ingredients: Lisinopril and Hydrochlorothiazide.


Do NOT use Prinizide if:

  • you are allergic to any ingredient in Prinizide or any other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid)
  • you have a history of angioedema (swelling of the face, lips, throat, or tongue)
  • you have a history of kidney artery narrowing
  • you are unable to urinate
  • you are taking dofetilide or ketanserin
  • you are pregnant.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Prinizide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are able to become pregnant
  • if you have impaired liver function, blood vessel problems (eg, stroke), heart disease (eg, congestive heart failure), or high cholesterol
  • if you have a history of kidney artery narrowing or decreased kidney function, you are on dialysis, or you have had a kidney transplant
  • if you have gout, diabetes, or electrolyte imbalances (eg, high or low potassium levels, low blood sodium levels), or you are on a sodium-restricted diet
  • if you have a collagen vascular disorder (eg, lupus, scleroderma), bone marrow problems, or severe immune system problems
  • if you have a history of allergies or asthma
  • if you are scheduled to have major surgery or receive anesthesia.

Some medicines may interact with Prinizide. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aldosterone blockers (eg, eplerenone), corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, lithium, loop diuretics (eg, furosemide), potassium preparations, potassium-sparing diuretics (eg, triameterene), or trimethoprim because the risk of electrolyte problems and irregular heartbeat may be increased
  • Barbiturates (eg, phenobarbital), dextran sulfate, diazoxide, or narcotic pain medicine (eg, codeine) because the risk of low blood pressure may be increased
  • Gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) because they may decrease Prinizide's effectiveness
  • Insulin, sulfonylureas (eg, glyburide), or other medicines for diabetes (eg, metformin) because their effectiveness may be decreased by Prinizide.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prinizide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Prinizide may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Prinizide with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Prinizide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Drink plenty of fluids while taking Prinizide and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.
  • Diabetes patients - Prinizide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • A persistent, unproductive cough may occur. Tell your doctor if this occurs. Recovery is rapid when the medicine is stopped.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Prinizide may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.
  • Tell your doctor or dentist that you take Prinizide before you receive any medical or dental care, emergency care, or surgery.
  • Prinizide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Prinizide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Prinizide may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Prinizide.
  • Lab tests, including blood electrolytes, blood pressure, complete blood cell counts, and kidney function, may be performed while you use Prinizide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Prinizide with caution in the elderly; they may be more sensitive to its effects.
  • Prinizide should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: Prinizide may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Prinizide is found in breast milk. Do not breastfeed while taking Prinizide.


All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; headache; lightheadedness; nausea; persistent nonproductive cough; tiredness; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; confusion; dark urine; fainting; fast, slow, or irregular heartbeat; increased thirst; joint pain, stiffness, or swelling; muscle cramps or weakness; numbness or tingling of hands or feet; persistent and unusual stomach pain; persistent sore throat or fever; red, swollen, or blistered skin; severe dizziness or lightheadedness; shortness of breath; sudden unusual weight loss or gain; trouble swallowing; unusual bruising or bleeding; unusual or severe weakness or tiredness; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Incidence Not Known

  • Abdominal or stomach pain
  • back, leg, or stomach pains
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • blood in the urine or stools
  • bloody urine
  • blue lips and fingernails
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clay-colored stools
  • cloudy urine
  • cold sweats
  • confusion
  • constipation
  • cough or hoarseness
  • coughing that sometimes produces a pink frothy sputum
  • coughing up blood
  • cracks in the skin
  • darkened urine
  • decrease in urine output or decrease in urine-concentrating ability
  • decreased frequency or amount of urine
  • diarrhea
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • dry mouth
  • fast or irregular heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • general body swelling
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • hives
  • increased blood pressure
  • increased hunger
  • increased sweating
  • increased thirst
  • increased urination
  • indigestion
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • loss of heat from the body
  • lower back or side pain
  • muscle cramps or pain
  • nausea or vomiting
  • nosebleeds
  • numbness, tingling, pain, or weakness in the hands or feet
  • pain in the joints or muscles
  • painful or difficult urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • redness, soreness, or itching skin
  • scaly skin
  • seizures
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sores, welting, or blisters
  • sugar in the urine
  • swelling of the face, fingers, legs, ankles, feet, or lower legs
  • swollen or painful glands
  • tenderness of salivary glands
  • thickening of bronchial secretions
  • tightness in the chest
  • trembling
  • troubled breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight loss
  • vomiting of blood
  • weakness and heaviness of the legs
  • weight gain
  • wheezing
  • yellow eyes or skin
  • Cramping
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • feeling of constant movement of self or surroundings
  • hair loss or thinning of the hair
  • inability to have or keep an erection
  • increased sensitivity of the skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • muscle spasm
  • pinpoint red or purple spots on the skin
  • redness or other discoloration of the skin
  • restlessness
  • sensation of spinning
  • severe sunburn
  • weakness
Type Small Molecule
Accession Number DB00999  (APRD00092)
Groups Approved, Vet approved
  • HCTZ
CAS number 58-93-5
Weight Average: 297.739
Monoisotopic: 296.964474846
Chemical Formula C7H8ClN3O4S2
Protein binding



The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in the mouse and rat.

Half life

5.6 and 14.8 hours

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  • Algiers
  • Oran
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  • Touggourt
  • Ghardaïa
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  • Tindouf
  • Tizi Ouzou