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PMS-Bisoprolol (Brand name: Zebeta)

  • $0.28
  • Brand name: Zebeta
  • Availability: In Stock
  • Active Ingredient Bisoprolol
PMS-Bisoprolol is a beta-blocker, indicated to treat high blood pressure employed alone or in combination with other antihypertensive drugs.
Other names of PMS-Bisoprolol (Brand name: Zebeta): a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Azopsin   Avecor   Antipres   Adco-Bisocor   Alotendin   Ancor   Apo Bisoprolol   Apo-Bisoprolol   Actim   Adco Bisco   Adroten   An Shi   Ancor Plus   PMS-Bisoprolol  
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10 mg
Product name Per Pill Per Pack  
60 pills $0.59 $35.48
90 pills $0.49 $53.23 $43.86
120 pills $0.44 $70.97 $52.24
180 pills $0.38 $106.45 $68.98
270 pills $0.35 $159.68 $94.10
360 pills $0.33 $212.90 $119.23
5 mg
Product name Per Pill Per Pack  
60 pills $0.55 $32.92
90 pills $0.45 $49.37 $40.29
120 pills $0.40 $65.83 $47.66
180 pills $0.35 $98.75 $62.41
270 pills $0.31 $148.12 $84.54
360 pills $0.30 $197.50 $106.67
2.5 mg
Product name Per Pill Per Pack  
60 pills $0.52 $31.08
90 pills $0.42 $46.62 $38.04
120 pills $0.38 $62.16 $45.00
180 pills $0.33 $93.24 $58.93
270 pills $0.30 $139.86 $79.81
360 pills $0.28 $186.48 $100.69

Common use

PMS-Bisoprolol contains active ingredient Bisoprolol Fumarate and belongs to a class of drugs called beta-adrenergic receptor blocking agents. Mechanism of its action is to prevent the chemicals transmitting nervous signal between nerves such as norepinephrine and adrenaline to bind receptors on nerves. This way heart rate and blood pressure are reduced as force of heart contractions and tone of blood vessels diminish.

Dosage and direction

Take exactly when it is prescribed by your doctor, do not change your dose and stop taking the rug suddenly as it may affect your self-condition.

Precautions

This medication influences ability  of attention concentration, so be specially careful if you need to drive or do work which requires fast reaction. Before taking PMS-Bisoprolol inform your doctor if you suffer from diabetes, psoriasis, predisposed to spasms of bronchi (asthmatic bronchitis, asthma, emphysema) or plan to be operated.

Contraindications

Hypersensitivity, cardiogenic shock, atrioventricular block (degree II and III), sick sinus syndrome, bradicardia (heart rate less than 50 per minute), severe hypotension, disorders of peripheral blood flow of patients who are treated with MAO inhibitors,  patients with chronic heart failure (heart rate less than 60 per minute) pregnancy, breastfeeding, children younger than 12 y.o.

Possible side effect

Side effects are generally transient as PMS-Bisoprolol is well tolerated. If you experience serious symptoms of confusion, hallucinations, nausea, impotence, slow heart rate, low blood pressure, numbness, tingling, cold extremities, pain or burning when you urinate, sore throat, and shortness of breath or wheezing, cramps, diarrhea, dizziness, fatigue, depression, headache, seek for immediate medical attention.

Drug interaction

Rifampin is able to diminish effects of PMS-Bisoprolol as it facilitates its metabolism. Ca+ channel blocks and digoxin can enhance effect of PMS-Bisoprolol which may cause extremely low rate of the heart. PMS-Bisoprolol should be administered two weeks after treatment with MAO inhibitors was discontinued.

Missed dose

If you missed a dose, take it as soon as you remember, but do not take it  if it is 4 hours only till the next intake by your schedule. If so skip the missed dose. Do not try to compensate a missed dose by taking an extra one.

Overdose

If you suspect that you took too much of PMS-Bisoprolol and experience slow heart rate, wheezing or shortness of breath, dizziness, anxiety, confusion, nausea, sweating, pale skin, fainting, and seizure, seek for immediate medical attention.

Storage

The medication should be stored at room temperature 15-30 C (59-86 F) in a light- resistant box.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Rare

  • Chest discomfort
  • lightheadedness, dizziness, or fainting
  • slow or irregular heartbeat

Less Common

  • Body aches or pain
  • chest pain
  • chills
  • cough
  • difficult or labored breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • pain or tenderness around eyes and cheekbones
  • shortness of breath or troubled breathing
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing
  • Abnormal or decreased touch sensation
  • diarrhea
  • difficulty in moving
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in joints
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • vomiting
Type Small Molecule
Accession Number DB00612  (APRD00257)
Groups Approved
Synonyms
  • (+-)-1-((alpha-(2-Isopropoxyethoxy)-P-tolyl)oxy)-3-(isopropylamino)-2-propanol
  • (RS)-1-(4-(2-isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol
  • Bisoprolol
  • Bisoprololum
UNII Y41JS2NL6U
CAS number 66722-44-9
Weight Average: 325.443
Monoisotopic: 325.225308485
Chemical Formula C18H31NO4
InChI
InChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3
IUPAC Name
1-[(propan-2-yl)amino]-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol
Protein binding

Binding to serum proteins is approximately 30%

Toxicity

Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 200 mg/kg; Skin, rat: LD50 = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.

Half life

9-12 hours; prolonged in the elderly and those with decreased renal function

Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:

  • Algiers
  • Oran
  • Constantine
  • Annaba
  • Blida
  • Batna
  • Djelfa
  • Sétif
  • Sidi Bel Abbès
  • Biskra
  • Tébessa
  • El Oued
  • Skikda
  • Tiaret
  • Béjaïa
  • Tlemcen
  • Ouargla
  • Béchar
  • Mostaganem
  • Bordj Bou Arréridj
  • Chlef
  • Souk Ahras
  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou