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Perindopril tert-butylamine/Amlodipine Servier (Brand name: Norvasc)
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Perindopril tert-butylamine/Amlodipine Servier (Brand name: Norvasc)

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  • $0.30
  • Brand name: Norvasc
  • Availability: In Stock
  • Active Ingredient amlodipine
Perindopril tert-butylamine/Amlodipine Servier is a calcium channel blocker prescribed to treat hypertension, chemic heart disease, angina.
Other names of Perindopril tert-butylamine/Amlodipine Servier (Brand name: Norvasc): a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
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10 mg
Product name Per Pill Per Pack  
30 pills $1.07 $32.06
60 pills $0.84 $64.13 $50.48
90 pills $0.77 $96.19 $68.90
120 pills $0.73 $128.26 $87.32
180 pills $0.69 $192.38 $124.16
270 pills $0.66 $288.58 $179.44
360 pills $0.65 $384.77 $234.68
2.5 mg
Product name Per Pill Per Pack  
90 pills $0.41 $36.45
180 pills $0.34 $72.90 $60.75
270 pills $0.32 $109.35 $85.05
360 pills $0.30 $145.80 $109.37
5 mg
Product name Per Pill Per Pack  
90 pills $0.48 $43.30
180 pills $0.40 $86.60 $72.74
270 pills $0.38 $129.90 $102.20
360 pills $0.37 $173.20 $131.65

Common use

This medication belongs to the group of calcium channel blockers. Perindopril tert-butylamine/Amlodipine Servier selectively blocks channels of L-type (one of six types of channels in tissues) located in a vascular wall, myocard and in particular in cells of conducting and contractile systems of myocardium. By blocking Ca+ ions transfer through membrane Perindopril tert-butylamine/Amlodipine Servier decreases tone of vessels, arterial pressure. The medication is used to treat hypertension, ischemic heart disease, angina.

Dosage and direction

Do not take this drug if it was not administered to you. Follow all directions of your doctor. It is possible to take Perindopril tert-butylamine/Amlodipine Servier with or without food. As it is metabolized in liver it should be administered cautiously in patients with liver failure.

Precautions

Avoid drinking alcohol. Before taking Perindopril tert-butylamine/Amlodipine Servier, inform your doctor if you have congestive heart failure or liver disease.

Contraindications

Individual hypersensitivity, arterial hypotension, cardiogenic shock, pregnancy, breastfeeding. Cautiousness is important when Perindopril tert-butylamine/Amlodipine Servier is administered in patients with chronic heart failure diabetes, lipid metabolism disorders, liver failure and to persons younger 18 y.o.

Possible side effect

The most common side effects are edema of lower extremities and headache. Contact your doctor for medical attention if your feel them and also swelling in your hands, ankles, or feet, chest pain, slow, fast, or pounding heartbeats, easy bruising or bleeding, unusual weakness, numbness, burning, pain, or tingly feeling, jaundice.

Drug interaction

Medications which contain Á2+ may decrease Perindopril tert-butylamine/Amlodipine Servier effect. Non-steroid anti-inflammatory medications and estrogens may decrease effectiveness of Perindopril tert-butylamine/Amlodipine Servier. Diuretics may increase Perindopril tert-butylamine/Amlodipine Servier activity. Concomitant taking with medications containing lithium might aggravate their toxicity.

Missed dose

If you forgot to take a dose take it as soon as you remember unless it is almost time for the next intake. If so, do not take the missed dose and resume your regular schedule. Do not compensate the missed dose by taking an extra one.

Overdose

If you experience tingly feeling, severe dizziness, and fainting, seek for immediate medical help.

Storage

Keep at room temperature, 15-30 C (59-86 F), in a light-resistant container away from moisture.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Rare

  • Black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chills
  • cold and clammy skin
  • cold sweats
  • confusion
  • dark yellow urine
  • cough
  • diarrhea
  • dilated neck veins
  • dizziness or lightheadedness when getting up from a lying or sitting position
  • extra heartbeats
  • extreme fatigue
  • fainting
  • fever
  • itching of the skin
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • numbness and tingling of the face, fingers, or toes
  • pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion
  • painful or difficult urination
  • pale, bluish-colored, or cold hands or feet
  • pinpoint red or purple spots on the skin
  • red, irritated eyes
  • redness of the face, neck, arms, and occasionally, upper chest
  • redness, soreness or itching skin
  • shakiness in the legs, arms, hands, or feet
  • slow or irregular heartbeat
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sores, welting, or blisters
  • sudden sweating
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen glands
  • trembling or shaking of the hands or feet
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weak or absent pulses in the legs
  • weakness in the arms, hands, legs, or feet
  • weight gain
  • yellow eyes or skin
  • Abnormal dreams
  • anxiety
  • back pain
  • bad unusual or unpleasant (after) taste
  • bleeding gums
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloating
  • bloody nose
  • burning feeling in the chest or stomach
  • burning while urinating
  • burning, dry, or itching eyes
  • change in color of the treated skin
  • change in sense of smell
  • change in taste
  • changes in vision
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cracked, dry, or scaly skin
  • decreased sexual performance or desire
  • depression
  • difficulty with moving
  • difficulty with swallowing
  • discharge, excessive tearing
  • double vision
  • dry mouth
  • dryness of the skin
  • excess air or gas in the stomach or intestines
  • excessive muscle tone
  • eye pain
  • feeling of constant movement of self or surroundings
  • feeling of unreality
  • feeling unusually cold
  • flushed, dry skin
  • fruit-like breath odor
  • full feeling
  • general feeling of discomfort or illness
  • hair loss or thinning of the hair
  • headache, severe and throbbing
  • hearing loss
  • hyperventilation
  • increased appetite
  • increased hunger
  • increased sweating
  • increased thirst
  • increased urge to urinate during the night
  • increased urination
  • irritability
  • irritation in the mouth
  • lack of feeling or emotion
  • loose stools
  • loss of memory
  • muscle pains or stiffness
  • muscle tension or tightness
  • muscle weakness
  • nervousness
  • pain
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • passing gas
  • problems with memory
  • redness and swelling of the gums
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • restlessness
  • runny nose
  • seeing double
  • sensation of spinning
  • sense of detachment from self or body
  • shakiness and unsteady walk
  • shivering
  • sleeplessness
  • sneezing
  • stuffy nose
  • sweating
  • swollen joints
  • tenderness in the stomach area
  • thirst
  • trouble in holding or releasing urine
  • trouble sleeping
  • twitching
  • unable to sleep
  • uncaring
  • unexplained weight loss
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • waking to urinate at night
  • weight loss

More Common

  • Swelling of the ankles or feet

Less Common

  • Difficult or labored breathing
  • dizziness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • shortness of breath
  • tightness in the chest
  • wheezing
  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • lack or loss of strength
  • muscle cramps
  • sleepiness or unusual drowsiness
  • stomach discomfort, upset, or pain

Incidence Not Known

  • Abdominal or stomach pain
  • clay-colored stools
  • diarrhea
  • headache
  • loss of appetite
  • nausea
  • rash
  • unpleasant breath odor
  • vomiting of blood
  • yellow eyes or skin
  • Swelling of the breasts or breast soreness in both females and males
Type Small Molecule
Accession Number DB00381  (APRD00520)
Groups Approved
Synonyms
  • (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • 3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
  • 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
  • Amlodipine
  • Amlodipine free base
  • Amlodipino
  • Amlodipinum
UNII 1J444QC288
CAS number 88150-42-9
Weight Average: 408.876
Monoisotopic: 408.145199627
Chemical Formula C20H25ClN2O5
InChI
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
IUPAC Name
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Protein binding

97.5%
Toxicity

Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.
Half life

30-50 hours

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