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Perindopril tert-butylamine/Amlodipine Servier (Brand name: Norvasc)
- $0.30
Avistar Atloma Astudal Arterium Asomex Arteriosan Apo-amlodipine Apo-amlo Apitim Antacal Anlodipin Anlow Angipec Angiovan gmp Angiofilina Anexa Amze Amvasc Amtim Amtas Ampin Amparo Amonex Amodipin Amocal Amlozek Amlow Amlovask Amlovasc Amlovas Amlotop Amlotens Amlotan Amlosyn Amlosun Amlostad Amlosin Amlorus Amloreg Amloratio Amlor Amlopres Amlopp Amlopol Amlopin Amlonor Amlong Amlomark Amlomal Amlolich Amlokard Amlohexal Amlogal Amlodowin Amlodipinum Amlodis Amlodipino Amlodipinbesilat Amlodipina Amlodipin Amlodinova Amlodine Amlodin Amlodilan Amlodil Amlodigamma Amlodibene Amlodep Amlode Amlodac Amlocor Amloclair Amlocard Amlocar Amloc Amloblock Amlobesyl Amlo Amlist Amlipin Amlip Amlid Amlibon Amlate Amlarrow Amilopid Amilo Amilip Amdopin Amdocal Amdixal Amdipin Amcor Amaday Alozur Alopres Alopine Almirin Almidis Almadin Aldosion Aldan Akridipin Aggovask Agen Adipin Actapin Abloom Abis Abesyl Amlodipin Amlodipino Amlodipina Amlodipine Besilate Amlodipine Besylate Amlodipine Maleate Abecab Abloom Abrea A-Card-AM Acerycal Acord Acord-A Acord-L Actiblok-AM Adblock-AT Adipin Adipin Plus Adipine Adipin-L Afiten Agen Aldan Aldosion Alea Alkapress Alkapress Plus Almacor Alneta Alortia Alotendin Amace Amace-BP Amat Ambelin Amcard Amcard-AT Amcard-LP Amcopine Amdepin Amdepin Duo Amdepin-AT Amdip Amdipin H Lafrancol Amdipin Lafrancol Amdocal Amdonex-AT Amdopin Amdopril Amdova Amelior Amelior plus HCT Amilo Amirap Amitor Amlator Amlaxopin Amlessa Amlibon Amlibon B Sandoz Amlip Amlo Amlo Ace Amlo TAD Amloact Amloact-AT Amloat Amloc Amlocal-AT Amlocar Amlocard Amlocard Plus Amlocard-A Amlocard-AX Amlocardin Amlo-CB Amlocim Amlocom Amlocom-AT Amlocor Amlod Amlodac-L Amlodar Amlodigamma Amlodik Amlodil Amlodin Amlodine Amlodipin - 1 A Pharma Amlodipin Actavis Amlodipin Alkaloid Amlodipin Jaka Amlodipin M.D. Mini Amlodipin Medochemie Amlodipin PharmaS Amlodipin Pharmaswiss Amlodipin ReplekFarm Amlodipin Teva Amlodipin Zdravlje Amlodipina Accord Amlodipina Farmoz Amlodipina Ilab Amlodipina Kronos Amlodipina Northia Amlodipina Vannier Amlodipine Amlodipine 123ratio Amlodipine Accord Amlodipine Amriya Amlodipine Aurobindo Amlodipine BioPolus Amlodipine Bluefish Amlodipine Corpus Medica Amlodipine Fair-Med Amlodipine Generico Amlodipine Medilink Amlodipine Medochemie Amlodipine Medreg Amlodipine NeoFarma Amlodipine Pharmachemie Amlodipine Pharmasin Amlodipine Vitabalans Amlodipine Wockhardt Amlodipine Zentiva Amlodipine/Atorvastatin Pfizer Amlodipine/Atorvastatine Krka Amlodipine/Iasis Amlodipino Ascend Amlodipino Besilato Amlodipino Bussié Amlodipino Chemopharma Amlodipino Farmandina Amlodipino Genfar Amlodipino L.CH. 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Lek Pharm Amlodipine Actavis Amlodipine Almus Amlodipine Alter Amlodipine Amer Amlodipine Apotex Amlodipine Arrow Amlodipine Arrow Generiques Amlodipine Bes Amlodipine Besilate Norma Amlodipine Besylate and Benazepril Hydrochloride Actavis Amlodipine Besylate Soho Amlodipine Biogaran Amlodipine BMD Amlodipine Bouchara-Recordati Amlodipine CH Amlodipine Chemipha Amlodipine Cristers Amlodipine DSEP Amlodipine EG Amlodipine EMEC Amlodipine Evolugen Amlodipine F Amlodipine Fahrenheit Amlodipine FDC Amlodipine Fuso Amlodipine Generichealth Amlodipine Heumann Amlodipine Hexpharm Amlodipine Isei Amlodipine Isomed Amlodipine Iwaki Amlodipine JG Amlodipine Jubilant Amlodipine Kaken Amlodipine KN Amlodipine Kowa Amlodipine Kukje Amlodipine MED Amlodipine Medica Amlodipine Meiji Amlodipine Mylan Amlodipine Nichi-iko Amlodipine NikP Amlodipine Norma Amlodipine NS Amlodipine OD Amer Amlodipine OD CH Amlodipine OD Chemipha Amlodipine OD EMEC Amlodipine OD Fuso Amlodipine OD JG Amlodipine OD Kaken Amlodipine OD KN Amlodipine OD KRM Amlodipine OD Kyorin Amlodipine OD Meiji Amlodipine OD Nichi-iko Amlodipine OD NS Amlodipine OD Sandoz Amlodipine OD Sawai Amlodipine OD Taiyo Amlodipine OD Takata Amlodipine OD TCK Amlodipine OD Towa Amlodipine OD TYK Amlodipine OD YD Amlodipine OD ZE Amlodipine OGB Medikon Amlodipine Ohara Amlodipine Orchid Europe Amlodipine PCH Amlodipine Pfizer Amlodipine PH Amlodipine Pharmaswiss Amlodipine PHR Lab Amlodipine QQ Amlodipine Ranbaxy Amlodipine ratio Amlodipine Ratiopharm Amlodipine Sandoz Amlodipine Sanis Health Amlodipine Sawai Amlodipine Stichting Amlodipine Taiyo Amlodipine Takata Amlodipine Tanabe Amlodipine TCK Amlodipine Teva Amlodipine Towa Amlodipine TYK Amlodipine Winthrop Amlodipine Wörwag Amlodipine YD Amlodipine ZJ Amlodipine Zydus Amlodipine/Atorvastatin Actavis Amlodipinebesilaat CF Amlodipinebesilaat STADA Amlodipine-GA Amlodipine-Teva Amlodipino Actavis Amlodipino Almus Amlodipino Alter Amlodipino Apotex Amlodipino Aurobindo Amlodipino BD-Mabo Amlodipino Bexal Amlodipino Bluefish Amlodipino Cinfa Amlodipino Combix Amlodipino Comprimidos Biosan Amlodipino Cuvefarma Amlodipino Ecar Amlodipino Ecuaquímica Amlodipino Kern Pharma Amlodipino Korhispana Amlodipino Mabo Amlodipino MK Amlodipino Mylan Amlodipino Normon Amlodipino Pensa Amlodipino Qualigen Amlodipino Ratiopharm Amlodipino Sandoz Amlodipino Tarbis Amlodipino Tecnigen Amlodipino Ur Amlodipino Uxa Amlodipino Vir Amlodipino Vir-Pharma Amlodipin-ratiopharm Amlodipin-Teva Amlodipin-Zentiva Amlodipress 1A Pharma Amlodno Amlogen Amloget Amlogrix Amlomak Amlonex Amlonorm Amlop Amlopac Amlopen Amlopin S Amlopol Amlopres Amlopres-AT Amlopress Amlopres-Z Amlo-Q besilat Amloratio Amloretin Amlosafe Amlosilat Amlosyl Amlotab Amlotac Amlotens Amlotop Amlotrene Amlovan Amlovask Amlovin-E Amlovin-H Amlowan Amlozaar Amlozen Amndiline Amnique Amo Amodep Amodep-AT Amodip Amodipan Amolab-5 Amolin Amonex Amopine Amoriro Ampilife-AT Amplex Ampliron VL Amrx Amtrel Amvalat Amvas Amvasc Amvasc BE Amvasc Plus An Nei Zhen Anam Anaten Angicam-LT Angiofilina Angioretic Angiovan gmp Anlo Anol-AD Antacal Anydipine S Apresa Aramax Aranda Arb-XG Armixxam Arplexam Arteriosan Arteriosan Plus Asomex Asomex-LT Astucor Astudal Atloma Atmos Atorcombo Atorvastatiin/Amlodipiin Krka Austell-Amlodipine Avistar Awadik Axcel Amlodipine Axeler Axyplot Azor Amosartan Amdixal Amlate Amlipin Amlodinova Amlodipin Heumann maleat Amlodipin Vim Amlodipina Cinfa Amlodipina Zentiva Amlodipine CF Amlodipine Focus Amlodipine Generics Amlodipine Krka Amlodipine P & D Amlodipine YES Amlodipino Teva Amlohexal Amlostad Amlostin Amlow Anydipine Ao Wan Lu A-Phine Tab Avevasc Amloclair Amlo-Denk Amlodilan Amlodipin +pharma Amlodipin AL Amlodipin G.L. Amlodipin Genericon Amlodipin Helvepharm Amlodipin Q-Pharm Amlodipin-1A Pharma Amlodipina Ciclum Amlodipina Stada Amlodipine Mesylate Dongwha Amlodipin-Mepha Amlodipino Davur Amlodipino Stada Amlopharm Amlovasc Perindopril tert-butylamine/Amlodipine Servier
Product name | Per Pill | Savings | Per Pack | |
---|---|---|---|---|
30 pills | $1.07 | $32.06 | ||
60 pills | $0.84 | $13.64 | $64.13 $50.48 | |
90 pills | $0.77 | $27.29 | $96.19 $68.90 | |
120 pills | $0.73 | $40.93 | $128.26 $87.32 | |
180 pills | $0.69 | $68.22 | $192.38 $124.16 | |
270 pills | $0.66 | $109.13 | $288.58 $179.44 | |
360 pills | $0.65 | $150.08 | $384.77 $234.68 |
Product name | Per Pill | Savings | Per Pack | |
---|---|---|---|---|
90 pills | $0.41 | $36.45 | ||
180 pills | $0.34 | $12.15 | $72.90 $60.75 | |
270 pills | $0.32 | $24.30 | $109.35 $85.05 | |
360 pills | $0.30 | $36.43 | $145.80 $109.37 |
Product name | Per Pill | Savings | Per Pack | |
---|---|---|---|---|
90 pills | $0.48 | $43.30 | ||
180 pills | $0.40 | $13.86 | $86.60 $72.74 | |
270 pills | $0.38 | $27.70 | $129.90 $102.20 | |
360 pills | $0.37 | $41.54 | $173.20 $131.65 |
Common use
This medication belongs to the group of calcium channel blockers. Perindopril tert-butylamine/Amlodipine Servier selectively blocks channels of L-type (one of six types of channels in tissues) located in a vascular wall, myocard and in particular in cells of conducting and contractile systems of myocardium. By blocking Ca+ ions transfer through membrane Perindopril tert-butylamine/Amlodipine Servier decreases tone of vessels, arterial pressure. The medication is used to treat hypertension, ischemic heart disease, angina.
Dosage and direction
Do not take this drug if it was not administered to you. Follow all directions of your doctor. It is possible to take Perindopril tert-butylamine/Amlodipine Servier with or without food. As it is metabolized in liver it should be administered cautiously in patients with liver failure.
Precautions
Avoid drinking alcohol. Before taking Perindopril tert-butylamine/Amlodipine Servier, inform your doctor if you have congestive heart failure or liver disease.
Contraindications
Individual hypersensitivity, arterial hypotension, cardiogenic shock, pregnancy, breastfeeding. Cautiousness is important when Perindopril tert-butylamine/Amlodipine Servier is administered in patients with chronic heart failure diabetes, lipid metabolism disorders, liver failure and to persons younger 18 y.o.
Possible side effect
The most common side effects are edema of lower extremities and headache. Contact your doctor for medical attention if your feel them and also swelling in your hands, ankles, or feet, chest pain, slow, fast, or pounding heartbeats, easy bruising or bleeding, unusual weakness, numbness, burning, pain, or tingly feeling, jaundice.
Drug interaction
Medications which contain Á2+ may decrease Perindopril tert-butylamine/Amlodipine Servier effect. Non-steroid anti-inflammatory medications and estrogens may decrease effectiveness of Perindopril tert-butylamine/Amlodipine Servier. Diuretics may increase Perindopril tert-butylamine/Amlodipine Servier activity. Concomitant taking with medications containing lithium might aggravate their toxicity.
Missed dose
If you forgot to take a dose take it as soon as you remember unless it is almost time for the next intake. If so, do not take the missed dose and resume your regular schedule. Do not compensate the missed dose by taking an extra one.
Overdose
If you experience tingly feeling, severe dizziness, and fainting, seek for immediate medical help.
Storage
Keep at room temperature, 15-30 C (59-86 F), in a light-resistant container away from moisture.
Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:
Rare
- Black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain or discomfort
- chills
- cold and clammy skin
- cold sweats
- confusion
- dark yellow urine
- cough
- diarrhea
- dilated neck veins
- dizziness or lightheadedness when getting up from a lying or sitting position
- extra heartbeats
- extreme fatigue
- fainting
- fever
- itching of the skin
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- numbness and tingling of the face, fingers, or toes
- pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion
- painful or difficult urination
- pale, bluish-colored, or cold hands or feet
- pinpoint red or purple spots on the skin
- red, irritated eyes
- redness of the face, neck, arms, and occasionally, upper chest
- redness, soreness or itching skin
- shakiness in the legs, arms, hands, or feet
- slow or irregular heartbeat
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- sores, welting, or blisters
- sudden sweating
- sweating
- swelling of the face, fingers, feet, or lower legs
- swollen glands
- trembling or shaking of the hands or feet
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- weak or absent pulses in the legs
- weakness in the arms, hands, legs, or feet
- weight gain
- yellow eyes or skin
- Abnormal dreams
- anxiety
- back pain
- bad unusual or unpleasant (after) taste
- bleeding gums
- blistering, crusting, irritation, itching, or reddening of the skin
- bloating
- bloody nose
- burning feeling in the chest or stomach
- burning while urinating
- burning, dry, or itching eyes
- change in color of the treated skin
- change in sense of smell
- change in taste
- changes in vision
- constipation
- continuing ringing or buzzing or other unexplained noise in the ears
- cracked, dry, or scaly skin
- decreased sexual performance or desire
- depression
- difficulty with moving
- difficulty with swallowing
- discharge, excessive tearing
- double vision
- dry mouth
- dryness of the skin
- excess air or gas in the stomach or intestines
- excessive muscle tone
- eye pain
- feeling of constant movement of self or surroundings
- feeling of unreality
- feeling unusually cold
- flushed, dry skin
- fruit-like breath odor
- full feeling
- general feeling of discomfort or illness
- hair loss or thinning of the hair
- headache, severe and throbbing
- hearing loss
- hyperventilation
- increased appetite
- increased hunger
- increased sweating
- increased thirst
- increased urge to urinate during the night
- increased urination
- irritability
- irritation in the mouth
- lack of feeling or emotion
- loose stools
- loss of memory
- muscle pains or stiffness
- muscle tension or tightness
- muscle weakness
- nervousness
- pain
- pains in the stomach, side, or abdomen, possibly radiating to the back
- passing gas
- problems with memory
- redness and swelling of the gums
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- restlessness
- runny nose
- seeing double
- sensation of spinning
- sense of detachment from self or body
- shakiness and unsteady walk
- shivering
- sleeplessness
- sneezing
- stuffy nose
- sweating
- swollen joints
- tenderness in the stomach area
- thirst
- trouble in holding or releasing urine
- trouble sleeping
- twitching
- unable to sleep
- uncaring
- unexplained weight loss
- unsteadiness, trembling, or other problems with muscle control or coordination
- waking to urinate at night
- weight loss
More Common
- Swelling of the ankles or feet
Less Common
- Difficult or labored breathing
- dizziness
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling of warmth
- redness of the face, neck, arms, and occasionally, upper chest
- shortness of breath
- tightness in the chest
- wheezing
- Acid or sour stomach
- belching
- heartburn
- indigestion
- lack or loss of strength
- muscle cramps
- sleepiness or unusual drowsiness
- stomach discomfort, upset, or pain
Incidence Not Known
- Abdominal or stomach pain
- clay-colored stools
- diarrhea
- headache
- loss of appetite
- nausea
- rash
- unpleasant breath odor
- vomiting of blood
- yellow eyes or skin
- Swelling of the breasts or breast soreness in both females and males
Type | Small Molecule |
Accession Number | DB00381 (APRD00520) |
Groups | Approved |
Synonyms |
|
UNII | 1J444QC288 |
CAS number | 88150-42-9 |
Weight | Average: 408.876 Monoisotopic: 408.145199627 |
Chemical Formula | C20H25ClN2O5 |
InChI | InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 |
IUPAC Name | 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
Protein binding | 97.5% |
Toxicity | Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported. |
Half life | 30-50 hours |
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