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Paracefan (Brand name: Clonidine)

  • $0.26
  • Brand name: Clonidine
  • Availability: In Stock
  • Active Ingredient clonidine
Conidine is an alpha-agonist hypotensive agent used to decrease blood pressure employed alone or in combination with other antihypertensive drugs.
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Atensina   Aruclonin   Arkamin   Apo-Clonidine   Arkamin   Arkamin-H   Aruclonin   Paracefan  
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0.1 mg
Product name Per Pill Per Pack  
60 pills $0.56 $33.77
90 pills $0.44 $50.66 $39.72
120 pills $0.38 $67.55 $45.66
180 pills $0.32 $101.32 $57.55
270 pills $0.28 $151.98 $75.38
360 pills $0.26 $202.64 $93.20

Common use

Paracefan may be used orally or as patches applied to your skin, it treats high blood pressure. It acts by changing the concentration of certain chemicals in blood and stimulating alpha2-adrenoceptors in the brain stem that reduces transmission of a signal from brain to other areas in the body. Its action results in a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.

Dosage and direction

Usually Paracefan is taken twice daily, the dosage depends on individual blood pressure response of a patient. Do not use this drug if it was not prescribed to you by your physician. In case you use patches they should be applied to an area of hairless skin on the upper arm or torso, once every 7 days. When you change the patch for a new one, choose a different area of skin.

Precautions

Avoid drinking alcohol, be especially attentive if you need to drive or make any work which requires high concentration of attention.

Contraindications

Hypersensitivity to Paracefan or any component of the formulation. Contraindication may be also applied to patients with sick sinus syndrome, bradicardia, atrioventricular block (degree II and III). Cautiousness should be exercised in cases of acute myocardial infraction, Reino syndrome, endogenous depression kidney failure and others.

Possible side effect

Aside of signs of allergic reaction such as hives, difficulty breathing, swelling such side effects may appear: fast or pounding heartbeats, a very slow heart rate, swelling, rapid weight gain, confusion, hallucinations, fever, pale skin, urinating less than usual. If you experience them seek for immediate medical attention.

Drug interaction

Paracefan causes increase of sedative effect of barbiturates, narcotic pain relievers and alcohol. Certain antidepressants may diminish pharmaceutical effect of Paracefan. Kidney damage maybe caused by increased concentration of Cyclosporine when Paracefan is administered concurrently. Concomitant prescription of Paracefan with medications which lower heart rate (beta-blockers) should be done with cautiousness.

Missed dose

If you missed a dose take it as soon as you remember, but if it is almost time of your next dose, just skip the forgotten dose. Do not try to compensate a missed dose by taking an extra one.

Overdose

If you suspect that you took too much of Paracefan and your blood pressure first becomes too high (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain) and then followed by low blood pressure (fainting, cold feeling, slow heart rate) seek for immediate medical attention.

Storage

Tablets and patches should be stored at room temperature 15-30 C (59-86 F) in a light- resistant container away from moisture.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Rare

  • Anxiety
  • blistering, burning, crusting, dryness, or flaking of the skin
  • chest pain or discomfort
  • confusion as to time, place, or person
  • decreased urine output
  • dilated neck veins
  • drowsiness
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • general feeling of discomfort or illness
  • holding false beliefs that cannot be changed by fact
  • hyperventilation
  • irregular breathing
  • irritability
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • mental depression
  • paleness or cold feeling in the fingertips and toes
  • pounding, slow heartbeat
  • problems in urination or increase in the amount of urine
  • raised red swellings on the skin, lips, tongue, or in the throat
  • restlessness
  • seeing or hearing things that are not there
  • shaking
  • shortness of breath
  • skin rash
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • tingling or pain in the fingers or toes when exposed to cold
  • trouble with sleeping
  • troubled breathing
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • vivid dreams or nightmares
  • weight gain
  • wheezing
  • Blurred vision
  • decreased interest in sexual intercourse
  • hair loss or thinning of the hair
  • inability to have or keep an erection
  • leg cramps
  • loss in sexual ability, desire, drive, or performance
  • muscle or joint pain
  • pale skin
  • swelling of the breasts or breast soreness in both females and males
  • weakness

More Common

  • Constipation

Less Common

  • Mental depression
  • swelling of the feet and lower legs
  • Darkening of the skin
  • decreased sexual ability
  • dry, itching, or burning eyes
  • loss of appetite
  • nausea or vomiting
Type Small Molecule
Accession Number DB00575  (APRD00174, DB07566)
Groups Approved
Synonyms
  • 2-[(2,6-Dichlorophenyl)imino]imidazoline
  • 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
  • Chlofazoline
  • Clonidin
  • Clonidina
  • Clonidinum
UNII MN3L5RMN02
CAS number 4205-90-7
Weight Average: 230.094
Monoisotopic: 229.017352717
Chemical Formula C9H9Cl2N3
InChI
InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
IUPAC Name
N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Protein binding

20-40%, primarily to albumin

Toxicity

Oral LD50 is 150 mg/kg in rat and 30 mg/kg in dog. Symptoms of overdose include constriction of pupils of the eye, drowsiness, high blood pressure followed by a drop in pressure, irritability, low body temperature, slowed breathing, slowed heartbeat, slowed reflexes, and weakness.

Half life

6-20 hours; 40-60% is excreted in urine unchanged, 20% is excreted in feces. Less than 10% is excreted by p-hydroxyclonidine.

Delivery is an important issue, when it comes to online shopping. Our platform is customer-oriented, so we are constantly working on expansion of delivery destinations. It features an international shipping option, which lets customers from all around the world get quality and effective remedies fast. Also delivery is available to many cities in Algeria, including the following:

  • Algiers
  • Oran
  • Constantine
  • Annaba
  • Blida
  • Batna
  • Djelfa
  • Sétif
  • Sidi Bel Abbès
  • Biskra
  • Tébessa
  • El Oued
  • Skikda
  • Tiaret
  • Béjaïa
  • Tlemcen
  • Ouargla
  • Béchar
  • Mostaganem
  • Bordj Bou Arréridj
  • Chlef
  • Souk Ahras
  • Médéa
  • El Eulma
  • Touggourt
  • Ghardaïa
  • Saïda
  • Laghouat
  • M'Sila
  • Jijel
  • Relizane
  • Guelma
  • Aïn Béïda
  • Khenchela
  • Bousaada
  • Mascara
  • Tindouf
  • Tizi Ouzou