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Perindopril tert-butylamine/Indapamide ratiopharm (Brand name: Aceon)
- $1.09
Asyntilsan Armix Apo-perindox Aldoc Agulan Acerycal Acertil Aceper Aceper Plus Acertil Acertil Plus Adwipril Agulan Amlessa Amra Amra forte Apo-Perindopril Armix Arginin Articel Acertil AR Acertil Plus Arginine Acerycal Aprestium Armixxam Arplexam Acesyl Acesyl Co Aldoc Aldoc DS Amradipin Apo-Perindo Apo-perindox Perindopril tert-butylamine/Indapamide ratiopharm
Product name | Per Pill | Savings | Per Pack | |
---|---|---|---|---|
30 pills | $1.92 | $57.46 | ||
60 pills | $1.52 | $23.92 | $114.91 $91.00 | |
90 pills | $1.38 | $47.84 | $172.37 $124.53 | |
120 pills | $1.32 | $71.75 | $229.82 $158.08 | |
180 pills | $1.25 | $119.57 | $344.74 $225.16 | |
270 pills | $1.21 | $191.32 | $517.10 $325.78 |
Product name | Per Pill | Savings | Per Pack | |
---|---|---|---|---|
30 pills | $1.70 | $51.08 | ||
60 pills | $1.37 | $20.06 | $102.15 $82.09 | |
90 pills | $1.26 | $40.11 | $153.23 $113.11 | |
120 pills | $1.20 | $60.18 | $204.30 $144.12 | |
180 pills | $1.15 | $100.30 | $306.45 $206.15 | |
270 pills | $1.11 | $160.46 | $459.68 $299.21 | |
360 pills | $1.09 | $220.64 | $612.90 $392.26 |
Product name | Per Pill | Savings | Per Pack | |
---|---|---|---|---|
30 pills | $2.87 | $86.16 | ||
60 pills | $2.29 | $34.90 | $172.33 $137.43 | |
90 pills | $2.10 | $69.80 | $258.49 $188.69 | |
120 pills | $2.00 | $104.69 | $344.65 $239.96 | |
180 pills | $1.90 | $174.47 | $516.98 $342.50 | |
270 pills | $1.84 | $279.18 | $775.47 $496.29 |
INDICATIONS
Perindopril tert-butylamine/Indapamide ratiopharm is used for treating high blood pressure. Perindopril tert-butylamine/Indapamide ratiopharm is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking ACE, an enzyme involved in narrowing blood vessels and causing sodium and fluid retention by the kidneys. This causes blood vessels to relax, allowing blood to flow more freely and at a lower pressure, and increasing the heart's ability to pump blood in some types of heart failure.
INSTRUCTIONS
Use Perindopril tert-butylamine/Indapamide ratiopharm as directed by your doctor.
- You may take Perindopril tert-butylamine/Indapamide ratiopharm with or without food.
- Take Perindopril tert-butylamine/Indapamide ratiopharm regularly to receive the most benefit from it. Taking Perindopril tert-butylamine/Indapamide ratiopharm at the same time each day will help you to remember to take it. Continue taking Perindopril tert-butylamine/Indapamide ratiopharm even if you feel well.
- If you miss a dose of Perindopril tert-butylamine/Indapamide ratiopharm, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Perindopril tert-butylamine/Indapamide ratiopharm.
MORE INFO:
Active Ingredient: Perindopril erbumine.
STORAGE
Store Perindopril tert-butylamine/Indapamide ratiopharm at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, light, and moisture. Keep Perindopril tert-butylamine/Indapamide ratiopharm out of the reach of children and away from pets.
SAFETY INFORMATION
Do NOT use Perindopril tert-butylamine/Indapamide ratiopharm if:
- you are allergic to any ingredient in Perindopril tert-butylamine/Indapamide ratiopharm
- you are in the second or third trimester of pregnancy
- you have a history of giant hives or skin inflammation caused by ACE inhibitors
- you are taking or have taken dextran sulfate within the past 3 days.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Perindopril tert-butylamine/Indapamide ratiopharm. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of giant hives or skin inflammation, or hardening of the skin or organs
- if you have bone marrow depression, blood vessel problems in the brain (including stroke), or severe immune system disease
- if you are undergoing dialysis
- if you have high blood potassium, low blood sodium, or are on a sodium-restricted diet
- if you have ischemic heart disease, liver or kidney problems (including transplant), or lupus, or you are dehydrated.
Some medicines may interact with Perindopril tert-butylamine/Indapamide ratiopharm. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Indomethacin, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or salicylates (eg, aspirin) because the effectiveness of Perindopril tert-butylamine/Indapamide ratiopharm may be decreased
- Clozapine, cyclosporine, dextran sulfate, HMG-CoA reductase inhibitors (eg, simvastatin), indomethacin, mannitol, NSAIDs (eg, ibuprofen), pergolide, phenothiazines (eg, chlorpromazine), potassium, potassium-sparing diuretics (eg, triamterene), thiazide-type diuretics (eg, hydrochlorothiazide), or trimethoprim because the actions and side effects of Perindopril tert-butylamine/Indapamide ratiopharm and these medicines may be increased.
- Iron, lithium, sulfonylureas (eg, glyburide), or thiopurines (eg, azathioprine) because the actions and side effects of these medicines may be increased.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Perindopril tert-butylamine/Indapamide ratiopharm may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Important safety information:
- Perindopril tert-butylamine/Indapamide ratiopharm may cause dizziness or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Perindopril tert-butylamine/Indapamide ratiopharm. Using Perindopril tert-butylamine/Indapamide ratiopharm alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
- Dizziness or lightheadedness may occur if you stand up too fast from a lying or sitting position. Avoid sudden changes in posture.
- Drink plenty of fluids while taking Perindopril tert-butylamine/Indapamide ratiopharm and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.
- A persistent, unproductive cough may occur. Tell your doctor if this occurs. Recovery is rapid when the medicine is stopped.
- Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning therapy. Continue taking our medicine even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms.
- Black patients are at higher risk for certain side effects, and may not respond as well to Perindopril tert-butylamine/Indapamide ratiopharm as patients of other races.
- Before you have any medical or dental treatments, emergency care, or surgery, tell your doctor or dentist that you are taking Perindopril tert-butylamine/Indapamide ratiopharm.
- Perindopril tert-butylamine/Indapamide ratiopharm may lower your resistance to infection. Prevent infection by avoiding contact with people with colds or other infections. Do not touch you eyes or the inside of your nose unless you have thoroughly washed your hands first.
- Do not use salt substitutes containing potassium without first talking with your health care provider.
- It may take several weeks for Perindopril tert-butylamine/Indapamide ratiopharm to work. Do not stop taking Perindopril tert-butylamine/Indapamide ratiopharm without checking with your health care provider.
- Lab tests, including liver function, kidney function, blood pressure, blood counts, and blood electrolytes, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
- Caution is advised when using Perindopril tert-butylamine/Indapamide ratiopharm in the elderly because they may be more sensitive to its effects, especially dizziness and rash.
- Children should use Perindopril tert-butylamine/Indapamide ratiopharm with extreme caution. Safety and effectiveness have not been confirmed.
- Pregnancy and breast-feeding: Perindopril tert-butylamine/Indapamide ratiopharm has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Perindopril tert-butylamine/Indapamide ratiopharm during pregnancy. It is unknown if Perindopril tert-butylamine/Indapamide ratiopharm is excreted in breast milk. Do not breast-feed while taking Perindopril tert-butylamine/Indapamide ratiopharm.
SIDE EFFECTS
All medicines may cause side effects, but many people have no, or minor, side effects.
Check with your doctor if any of these most common side effects persist or become bothersome:
Abnormal skin sensation; arm or leg pain; back pain; cough; depression; diarrhea; dizziness; drowsiness; headache; lightheadedness; nausea; runny nose; weakness.
Seek medical attention right away if any of these severe side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine; chest pain; darkening of urine; difficulty swallowing; fainting; fast or irregular heartbeat; fever; hoarseness; pounding in the chest; prolonged nausea, vomiting, or diarrhea; severe lightheadedness or fainting; sore throat; swelling of the hands, legs, face, lips, eyes, throat, tongue, or trunk; unusual joint pain; unusual muscle pain, cramps, or weakness; unusual stomach pain; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:
Rare
- Blurred vision
- confusion
- decreased urination
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- irregular heartbeat
- muscle cramps or pain
- numbness, tingling, pain, or weakness in the hands or feet
- rapid breathing
- seizures
- sunken eyes
- sweating
- thirst
- trembling
- weakness and heaviness of the legs
More Common
- Body aches or pain
- chills
- cough
- difficulty breathing
- ear congestion
- fever
- headache
- loss of voice
- nasal congestion
- runny nose
- sneezing
- sore throat
- unusual tiredness or weakness
- Back pain
- lack or loss of strength
- pain or tenderness around the eyes and cheekbones
- tightness of the chest
Less Common
- Bladder pain
- bloody or cloudy urine
- change in hearing
- chest pain
- cold
- congestion
- diarrhea
- difficult, burning, or painful urination
- dryness of the throat
- earache or pain in the ear
- ear drainage
- frequent urge to urinate
- general feeling of discomfort or illness
- hoarseness
- joint pain
- loss of appetite
- lower back or side pain
- nausea
- shivering
- stomach pain
- swelling
- tender, swollen glands in the neck
- trouble sleeping
- trouble with swallowing
- voice changes
- vomiting
- Belching
- bloated feeling
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- diarrhea
- difficulty moving
- discouragement
- excess air or gas in the stomach or intestines
- feeling of fullness
- feeling sad or empty
- hearing loss
- injury
- irritability
- leg pain
- loss of interest or pleasure
- muscle ache, stiffness, tension, or tightness
- neck pain
- nervousness
- pain, swelling, or redness in the joints
- passing of gas
- rash
- sleepiness or unusual drowsiness
- stomach discomfort or upset
- swollen joints
- trouble concentrating
Type | Small Molecule |
Accession Number | DB00790 (APRD01178) |
Groups | Approved |
Synonyms |
|
UNII | Y5GMK36KGY |
CAS number | 82834-16-0 |
Weight | Average: 368.4678 Monoisotopic: 368.231122144 |
Chemical Formula | C19H32N2O5 |
InChI | InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1 |
IUPAC Name | (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid |
Protein binding | Perindoprilat, 10-20% bound to plasma proteins |
Toxicity | The most likely symptom of overdose is severe hypotension. The most common adverse effects observed in controlled clinical trials include cough, digestive symptoms, fatigue, headache, and dizziness. |
Half life | Perindopril, 1.2 hours; Peridoprilat, 30-120 hours. The long half life of peridoprilat is due to its slow dissociation from ACE binding sites. |
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