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Pectylin (Brand name: Benadryl)

  • $1.73
  • Brand name: Benadryl
  • Availability: In Stock
  • Active Ingredient Diphenhydramine
Pectylin is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body. It is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; and other symptoms of allergies and the common cold.
Analogs of Pectylin (Brand name: Benadryl): Unisom   Sominex  
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25 mg
Product name Per Pill Per Pack  
60 pills $2.61 $156.86
90 pills $2.23 $235.30 $201.01
120 pills $2.04 $313.73 $245.16
180 pills $1.85 $470.59 $333.45
270 pills $1.73 $705.89 $465.89

INDICATIONS

Pectylin is used for preventing or treating symptoms of hay fever and other upper respiratory allergies or the common cold, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes, and relieving cough.

INSTRUCTIONS 

Do not take Pectylin if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Before taking Pectylin, tell your doctor if you have:

  • glaucoma or increased pressure in the eye;
  • a stomach ulcer;
  • an enlarged prostate, bladder problems or difficulty urinating;
  • an overactive thyroid (hyperthyroidism);
  • hypertension or any type of heart problems; or
  • asthma.


You may not be able to take Pectylin, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Take Pectylin exactly as directed on the package or as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Pectylin can be taken with or without food.

For motion sickness, a dose is usually taken 30 minutes before motion, then with meals and at bedtime for the duration of exposure.

As a sleep aid, Pectylin should be taken approximately 30 minutes before bedtime.

To ensure that you get a correct dose, measure the liquid forms of Pectylin with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Never take more of Pectylin than is prescribed for you. The maximum amount of diphenhydramine that you should take in any 24-hour period is 300 mg.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of Pectylin unless otherwise directed by your doctor.

DOSAGE

Do NOT use more than directed.

Adults and children 12 years of age and over - 25 mg to 50 mg (1 to 2 capsules).

Children 6 to under 12 years of age - 12.5 mg ** to 25 mg (1 capsule).

Children under 6 years of age - consult a doctor.

STORAGE

Store Pectylin at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pectylin out of the reach of children and away from pets.

SAFETY INFORMATION

Before taking diphenhydramine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e.g., asthma, emphysema), glaucoma, heart problems, high blood pressure, liver disease, mental/mood changes, seizures, stomach problems (e.g., ulcers, obstruction), an overactive thyroid gland, difficulty urinating (e.g., due to an enlarged prostate gland).

Pectylin is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take Pectylin without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of antihistamines, and side effects could occur in a breast-feeding baby. Do not take Pectylin without first talking to your doctor if you are nursing a baby.

If you are over 60 years of age, you may be more likely to experience side effects from Pectylin. You may require a lower dose of Pectylin.

SIDE EFFECTS

Stop taking Pectylin and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take Pectylin and talk to your doctor if you experience:

  • sleepiness, fatigue, or dizziness;
  • headache;
  • dry mouth; or
  • difficulty urinating or an enlarged prostate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

When using this product:

  • marked drowsiness may occur
  • avoid alcoholic drinks
  • alcohol, sedatives, and tranquilizers may increase drowsiness
  • excitability may occur, especially in children
  • be careful when driving a motor vehicle or operating machinery 
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Type Small Molecule
Accession Number DB01075  (APRD00587, DB06975)
Groups Approved, Investigational
Synonyms
  • 2-(Benzhydryloxy)-N,N-dimethylethylamine
  • 2-diphenylmethoxy-N,N-demthylethanamine
  • alpha-(2-Dimethylaminoethoxy)diphenylmethane
  • beta-Dimethylaminoethanol diphenylmethyl ether
  • beta-Dimethylaminoethyl benzhydryl ether
  • Difenhidramina
  • Diphenhydraminum
  • N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine
  • O-benzhydryldimethylaminoethanol
  • β-dimethylaminoethyl benzhydryl ether
UNII 8GTS82S83M
CAS number 58-73-1
Weight Average: 255.3547
Monoisotopic: 255.162314299
Chemical Formula C17H21NO
InChI
InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
IUPAC Name
[2-(diphenylmethoxy)ethyl]dimethylamine
Protein binding

98 to 99%

Toxicity

LD50=500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death.

Half life

1-4 hours

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