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Parocline (Brand name: Minocin)

  • $1.85
  • Brand name: Minocin
  • Availability: In Stock
  • Active Ingredient minocycline
Parocline is used to treat many different bacterial infections, such as urinary tract infections, severe acne, gonorrhea, tick fever, chlamydia, and others.
Analogs of Parocline (Brand name: Minocin): Minomycin  
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Other names of Parocline (Brand name: Minocin): a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Arestin   Aknosan   Aknoral   Aknemin   Akamin   Acneclin   Acnamino   Acneclin   Akamin   Aknemin   Aknosan   Apo-Minocycline   Parocline  
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50 mg
Product name Per Pill Per Pack  
15 pills $2.98 $44.70
30 pills $2.36 $89.40 $70.87
45 pills $2.16 $134.10 $97.04
60 pills $2.05 $178.79 $123.20
90 pills $1.95 $268.19 $175.55
120 pills $1.90 $357.59 $227.88
180 pills $1.85 $536.38 $332.55

INDICATIONS

Parocline is used for treating certain infections. It may also be used with other medicines to treat severe acne. Parocline is a tetracycline antibiotic. It works by slowing the growth of certain bacteria and allowing the body's immune system to kill them.

INSTRUCTIONS 

Use Parocline as directed by your doctor.

  • Some brands of Parocline may be taken with food. Others should be taken on an empty stomach. Check with your doctor or pharmacist about how to take your brand of Parocline.
  • Some brands of Parocline must be swallowed whole. Check with your doctor or pharmacist to see if your medicine is a brand that must be swallowed whole.
  • Take Parocline by mouth with or without food.
  • Take Parocline with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Parocline.
  • If you also take bismuth salts (eg, bismuth subsalicylate), calcium salts (eg, calcium carbonate), colestipol, iron salts (eg, iron sulfate), magnesium, urinary alkalinizers (eg, daily antacids), sucralfate, vitamins/minerals, quinapril, didanosine, or zinc salts (eg, zinc sulfate), do not take them within 2 to 3 hours before or after taking Parocline. Check with your doctor if you have questions.
  • To clear up your infection completely, take Parocline for the full course of treatment. Keep taking it even if you feel better in a few days.
  • Parocline works best if it is taken at the same time each day.
  • If you miss a dose of Parocline, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Parocline.

STORAGE

Store Parocline at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Parocline out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Minocycline hydrochloride.

SAFETY INFORMATION

Do NOT use Parocline if:

  • you are allergic to any ingredient in Parocline
  • you are taking acitretin, qisotretinoin, methoxyflurane, or a penicillin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Parocline. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems
  • if you have an autoimmune disorder (eg, lupus).

Some medicines may interact with Parocline. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aluminum salts (eg, carbonate) or cimetidine because they may decrease Parocline's effectiveness
  • Acitretin, anticoagulants (eg, warfarin), digoxin, ergot alkaloids (eg, ergotamine), insulin, isotretinoin, methotrexate, methoxyflurane, or theophyllines because the risk of their side effects may be increased by Parocline
  • Live oral typhoid vaccine, oral contraceptives (birth control pills), or penicillins because their effectiveness may be decreased by Parocline.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Parocline may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Parocline may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Parocline with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Parocline may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Parocline. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Long-term or repeated use of Parocline may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Parocline only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Tell your doctor or dentist that you take Parocline before you receive any medical or dental care, emergency care, or surgery.
  • Be sure to use Parocline for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Parocline. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Lab tests may be performed while you use Parocline. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Parocline with caution in the elderly; they may be more sensitive to its effects.
  • Use Parocline with extreme caution in children younger 10 years who have diarrhea or an infection of the stomach or bowel.
  • Parocline should not be used in children younger than 8 years old; safety and effectiveness in these children have not been confirmed. Using Parocline in children younger than 8 years old or in women during the last half of pregnancy may cause a permanent change in the tooth coloring of the child.
  • Pregnancy and breast-feeding: Parocline has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Parocline while you are pregnant. Parocline is found in breast milk. Do not breastfeed while taking Parocline.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; drowsiness; lightheadedness; loss of appetite; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; blurred vision; bulging soft spots in infants; fever; headache; increased pressure in the head; inflammation of the pancreas (increased pulse, nausea, stomach tenderness, vomiting); joint pain, muscle pain or weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe diarrhea; severe skin reaction to the sun; stomach pain/cramps; trouble swallowing; unusual tiredness or weakness; vaginal irritation or discharge; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Contact the support team to get instructions from qualified doctors as taking the treatment in accordance with the safety recommendations and instructions is halfway to a flawless and successful treatment course. Patients, who are hypersensitive to any ingredients of the remedy should avoid its use. The following mild to severe abnormalities can bother patients, who misuse or overuse the drug:

Less Common

  • Continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty with moving
  • hearing loss
  • hives or welts
  • muscle stiffness
  • redness of the skin
  • sleepiness or unusual drowsiness

Incidence Not Known

  • Black, tarry stools
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • blurred or double vision
  • bulging soft spot on the head of an infant
  • chest pain, possibly moving to the left arm, neck, or shoulder
  • confusion
  • diarrhea
  • dizziness or lightheadedness
  • eye pain
  • fast heartbeat
  • general feeling of discomfort or illness
  • general tiredness and weakness
  • hives, itching, or skin rash
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • nausea or vomiting
  • red skin lesions, often with a purple center
  • severe headache
  • severe stomach pain
  • sores, ulcers, or white spots on the lips or in the mouth
  • troubled breathing
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • yellow eyes and skin
  • Bloating
  • discoloration of the tooth
  • increased sensitivity of the skin to sunlight
  • indigestion
  • severe sunburn
Type Small Molecule
Accession Number DB01017  (APRD00547)
Groups Approved, Investigational
Synonyms
  • (4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • 7-Dimethylamino-6-demethyl-6-deoxytetracycline
  • Minociclina
  • Minociclinum
  • Minocyclin
  • Minocyclinum
UNII FYY3R43WGO
CAS number 10118-90-8
Weight Average: 457.4764
Monoisotopic: 457.184900233
Chemical Formula C23H27N3O7
InChI
InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1
IUPAC Name
(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Protein binding

55% to 76%

Toxicity

Minocycline has been observed to cause a dark discoloration of the thyroid in experimental animals (rats, minipigs, dogs and monkeys). In the rat, chronic treatment with minocycline has resulted in goiter accompanied by elevated radioactive iodine uptake and evidence of thyroid tumor production. Minocycline has also been found to produce thyroid hyperplasia in rats and dogs. LD50=2380 mg/kg (rat, oral), LD50=3600 mg/kg (mouse, oral)

Half life

11-22 hours

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  • Algiers
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  • Relizane
  • Guelma
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  • Tizi Ouzou